Chemotherapy for Leukemia

1. An Overview
Takanori Ueda

Part I. Bcr-Abl Tyrosine Kinase Inhibitors (TKIs)

2. Imatinib: Basic Results
Fujiko Tsukahara, Yoshiro Maru

3. Imatinib: Clinical Pharmacology and Therapeutic Results
Kazunori Ohnishi

4. Dasatinib, Nilotinib, Bosutinib, Ponatinib, and Other TKIs
Shinya Kimura

Part II. New Antibodies for Leukemia

5. Rituximab and Alemtuzumab for Chronic Lymphocytic Leukemia: Basic Results and Pharmacokinetics
Katsuki Sugiyama

6. Rituximab and Alemtuzumab for Chronic Lymphocytic Leukemia: Clinical Pharmacology and Therapeutic Results
Suguru Fukuhara, Kensei Tobinai

7. Inotuzumab Ozogamicin for Acute Lymphoblastic Leukemia: Clinical Pharmacology and Therapeutic Results
Noriko Usui

8. Blinatumomab for Acute Lymphoblastic Leukemia: Clinical Pharmacology and Therapeutic Results
Satoru Takada

9. Mogamulizumab in Adult T-Cell Leukemia/Lymphoma
Michinori Ogura

Part III. Signaling Inhibitors

10. FLT3 Inhibitors
Hitoshi Kiyoi

Part IV. Differentiating Agents

11. Retinoic Acid, All-trans Retinoic Acid (ATRA), and Tamibarotene
Norio Asou

12. The Molecular Basis of Arsenic Trioxide Treatment for Acute Promyelocytic Leukemia (APL)
Masahiro Kizaki

13. Arsenic Trioxide: Clinical Pharmacology and Therapeutic Results
Nobuhiko Emi

Part V. New Chemotherapeutic Agents Including Antimetabolite

14. Nelarabine
Takahiro Yamauchi, Takanori Ueda

15. Forodesine
Takahiro Yamauchi, Takanori Ueda

16. Clofarabine: Structure, Mechanism of Action, and Clinical Pharmacology
William B. Parker, Varsha Gandhi

17. Clinical Use of Clofarabine for Adults and Children with Leukemia
James McCloskey, Jamie Koprivnikar, Stefan Faderl, Dirk Reinhardt, Nobuko Hijiya

18. Re-emerging Antimetabolites with Novel Mechanism of Action with Respect to Epigenetic Regulation: Basic Aspects
Dzjemma Sarkisjan, Renske D. M. Steenbergen, Jacqueline Cloos, Godefridus J. Peters

19. Epigenetic Regulator, Re-emerging Antimetabolites with Novel Mechanism of Action (Azacitidine and Decitabine): Clinical Pharmacology and Therapeutic Results
Shinya Sato, Yasushi Miyazaki

Part VI. Therapy Targeting Leukemic Stem Cells

20. Therapies Targeting Leukemic Stem Cells
Taira Maekawa

Nyckelord: Medicine & Public Health, Oncology, Hematology