Moyamoya Disease Explored Through RNF213

Part I. Prologue

1. A Prologue to Moyamoya Disease and RNF213

Akio Koizumi, Shohab Youssefian

2. Concept of Moyamoya Disease
Haruto Uchino, Ken Kazumata, Kiyohiro Houkin

Part II. Genetic Epidemiology

3. Molecular Epidemiology in East Asian Countries and in the World
Wanyang Liu

Part III. Biochemistry, Function and Molecular Pathology

4. Molecular Biology of Mysterin/RNF213
Daisuke Morito, Kazuhiro Nagata

5. Physiological Role of Mysterin/RNF213 in Zebrafish
Daisuke Morito, Kazuhiro Nagata

6. Pathological Investigation on RNF213: Animal Models Knockout and Transgenic Mice in Diabetes and Signal Transduction
Hatasu Kobayashi

7. Pathological Investigation on RNF213: Animal Models of Rnf213-Knockout and Knock-in Mice
Miki Fujimura, Shigeo Kure, Teiji Tominaga

8.
RNF213 and Circulating Factors in Patients with Moyamoya Disease
Oh Young Bang

9. Genetics of Moyamoya Beyond RNF213: Monogenic Moyamoya Syndromes
S. Guey, M. Kraemer, L. Grangeon, F. Riant, M. Kossorotoff, D. Hervé, E. Tournier-Lasserve

Part IV. Clinical Management

10. Natural History and Long-Term Clinical Outcome After Conservative and Surgical Management
Won-Sang Cho, Jeong Eun Kim

11. Significance of RNF213 in Clinical Management in Japan
Yohei Mineharu, Yasushi Takagi, Susumu Miyamoto

12. Significance of RNF213 in Clinical Management in China
Zheng-Shan Zhang, Lian Duan

13. The Different Forms of Moyamoya Disease and Their Clinical Management
Niklas Spreckelsen, Boris Krischek

14. Vascular Diseases Attributable to RNF213 Other Than Moyamoya Disease
Satoru Miyawaki, Hideaki Imai, Nobuhito Saito

Part V. Epilogue

15. Future Clinical Perspectives on RNF213 in Moyamoya Disease
Shigeo Kure

Nyckelord: Medicine & Public Health, Neurology, Neurosurgery, Public Health