Hyperthermic Oncology from Bench to Bedside

Part I. Basic Science in Cultured Cells

1. Introduction
Satoshi Kokura

2. Induction of Oxidative Stress by Hyperthermia and Enhancement of Hyperthermia-Induced Apoptosis by Oxidative Stress Modification
Yoshiaki Tabuchi, Kanwal Ahmed, Takashi Kondo

3. Molecular Damage: Hyperthermia Alone
Akihisa Takahashi

4. Roles of HSF1 and Heat Shock Proteins in Cancer
Kenzo Ohtsuka

5. Cellular Responses in Signal Transduction Pathways Induced by Hyperthermia
Takeo Ohnishi

6. Cell Cycle Responses to Hyperthermia
Yukihiro Furusawa

7. Thermo-Tolerance
Ken Ohnishi

8. Enhancement of Hyperthermia on Radio-Sensitivity
Ken Ohnishi

9. Inhibition of DNA Repair System Activity
Akihisa Takahashi

10. Enhancement of Hyperthermia on Anti-tumor Drug Sensitivity
Takeo Ohnishi

11. Inhibition of Epithelial-to-Mesenchymal Transition (EMT) by Hyperthermia
Satoshi Kokura

Part II. Basic Science in Whole Body

12. Potentiating Immune System by Hyperthermia
Hiroshi Terunuma

13. Magnetic Nanoparticle-Mediated Hyperthermia and Induction of Anti-Tumor Immune Responses
Takeshi Kobayashi, Akira Ito, Hiroyuki Honda

14. Tumor Microenvironment and Hyperthermia
Shin-ichiro Masunaga

Part III. Clinical Science in Cancer Patients

15. Hyperthermia Alone
Takayuki Ohguri

16. Combination Therapy with Hyperthermia and Chemoradiotherapy: Oral Cancer
Kenji Mitsudo, Iwai Tohnai

17. Combination by Hyperthermia and Radiation (and Chemotherapy): Lung Cancer
Takayuki Ohguri

18. Efficacy of Hyperthermia in Combination with Radiation Therapy for Breast Cancer
Daigo Yamamoto, Chizuko Yamamoto, Satoru Iwase, Hiroki Odagiri

19. Combination by Hyperthermia and Radiation: Esophageal Cancer
Takayuki Ohguri

20. Combination by Hyperthermia and Radiotherapy and/or Chemo-radiotherapy: Gyneology Cancer
Yoko Harima

21. Combination by Hyperthermia and Radiation and Chemotherapy: Soft Tissue Sarcoma
Hisaki Aiba, Hiroaki Kimura, Takanobu Otsuka

22. Combination by Hyperthermia and Chemotherapy: Lung Cancer
Takayuki Ohguri

23. Efficacy of Hyperthermia in Combination With Chemotherapy for Breast Cancer
Daigo Yamamoto, Chizuko Yamamoto, Satoru Iwase, Hiroki Odagiri

24. Combination by Hyperthermia and Chemotherapy: Esophageal Cancer
Takayuki Ohguri

25. Combination with Hyperthermia and Chemotherapy: Liver Cancer
Satoshi Kokura

26. Hyperthermia Combined with Chemotherapy: Pancreatic Cancer
Takeshi Ishikawa

27. Effect of Hyperthermia in Combination with Chemotherapy and Radiation Therapy for Treatment of Urological Cancer: Prostate Cancer and Urothelial Cancer
Kosuke Ueda, Fumiko Maeda, Mayumi Oota

28. Combination by Hyperthermia and Surgery
Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi, Takashi Nakano

29. Combining Hyperthermia and Immunotherapy: NK Therapy and Hyperthermia
Hiroshi Terunuma, Noriyuki Nishino, Tsuyoshi Abe, Akiko Yoshimura, Atsushi Toki, Tatsuaki Ishiguro, Xuewen Deng, Atsushi Terunuma

30. Combination by Hyperthermia and Immunotherapy: DC Therapy and Hyperthermia
Tsutomu Takeda, Takashi Takeda

31. Effects of Fever-Range Hyperthermia on T Cell-Mediated Immunity: Possible Combination of Hyperthermia and T Cell-Based Cancer Immunotherapy
Keishi Tanigawa, Yusuke Ito, Yasunobu Kobayashi

32. Combination of Hyperthermia and Immunotherapy: Hyperthermia and Naïve T-cell Therapy
Satoshi Kokura

33. High-Temperature Hyperthermic Intraperitoneal Chemotherapy (H-HIPEC) with Cytoreductive Surgery for Patients with Peritoneal Metastases of Colorectal Cancer and Appendiceal Pseudomyxoma
Kanji Katayama, Mitsuhiro Morikawa, Kenji Koneri, Makoto Murakami, Yasuo Hirono, Takanori Goi, Akio Yamaguchi

34. A New Comprehensive Treatment for Peritoneal Metastases Using Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Chemoperfusion
Yutaka Yonemura, Akiyoshi Mizumoto, Haruaki Ishibashi, Kazuyoshi Takeshita, Oliver Glehen, Paul H. Sugarbaker

35. Noninvasive Temperature Monitoring
Kagayaki Kuroda

36. Development of Heating Device
Masahiro Kuroda, Kazuyuki Saito, Koichi Ito, Shin-ichiro Umemura

37. Epilogue
Takeo Ohnishi

Nyckelord: Medicine & Public Health, Radiotherapy, Oncology