DNA Alterations in Lynch Syndrome

1. Historical Development of Lynch Syndrome
Henry T. Lynch, Stephen J. Lanspa, Carrie L. Snyder, Trudy G. Shaw, Patrick M. Lynch

2. Molecular Mechanisms and Functions of DNA Mismatch Repair
Hui Geng, Peggy Hsieh

3. New Insights into Lynch Syndrome Diagnosis
Emile Coetzee, Ursula Algar, Paul Goldberg

4. Genetic Testing, an Optimal Strategy for Lynch Syndrome Identification
Petra Hudler

5. Functional Analyses Help to Assess the Pathogenicity of MMR Gene Variants of Uncertain Significance
Minna Nyström, Minttu Kansikas

6. The Role of Epimutations of the Mismatch Repair Genes in the Development of Lynch Syndrome Related Cancers
Megan P. Hitchins

7. Mutations in Non-MMR Genes Modifying or Mimicking Lynch Syndrome Phenotype
Mala Pande, Jinyun Chen, Chongjuan Wei, Yu-Jing Huang, Marsha L. Frazier

8. Lynch Syndrome: Genetic Counselling of At-Risk Individuals and Families
Zandrè Bruwer, Raj Ramesar

Nyckelord: Biomedicine, Cancer Research, Human Genetics, Molecular Medicine, Gastroenterology, Oncology