Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future

1. Time for New Guidelines in Handling of Neurodegenerative Disorders: Optimistic Versus Pessimistic Prognosis by Application of PPPM
Silvia Mandel, Olga Golubnitschaja

2. Individual Predispositions in Healthy Vasospastic Individuals: Patient Profiling for Targeted Prevention of “Down-Stream” Pathologies as Cost-Effective Personalised Medicine
Kristina Yeghiazaryan, Josef Flammer, Olga Golubnitschaja

3. Idiopathic REM Sleep Behavior Disorder as a Long-Term Predictor of Neurodegenerative Disorders
Stephany Fulda, Mauro Manconi

4. New Animal Models of Progressive Neurodegeneration: Tools for Developing Predictive Diagnostics and Identifying Presymptomatic Therapeutic Targets
Amber L. Marriott, Daphne A. Gill, Christopher A. Shaw, R. Andrew Tasker

5. Tau Pathology: A Selected View on the Current Status
Illana Gozes

6. The Use of Biomarkers for Prediction and Prevention of Alzheimer’s and Parkinson’s Diseases
Silvia Mandel, Amos D. Korczyn

7. Clinical Trials of AD Delay of Onset: Enrichment by a Prognostic Genetic Biomarker
Iris Grossman, Michael W. Lutz, Donna G. Crenshaw, Ann M. Saunders, Ornit Chiba-Falek, William K. Gottschalk, Allen D. Roses

8. An Update on CSF Biomarkers of Parkinson’s Disease
Peter A. LeWitt, Bertrand R. Huber, Jing Zhang

9. Glaucomatous Optic Neuropathy: Risk Assessment and Potential Targets for Effective Prevention and Treatments Tailored to the Patient
Olga Golubnitschaja, Kristina Yeghiazaryan, Josef Flammer

10. Toward a Personalized Approach in Amyotrophic Lateral Sclerosis: New Developments in Diagnosis, Genetics, Pathogenesis and Therapies
Beatrice Nefussy, Vivian E. Drory

11. Recent Advances in ALS Research: Perspectives for Personalized Clinical Application
Chen Benkler, Daniel Offen, Eldad Melamed, Tamar Amit, Silvia Mandel, Moussa B. H. Youdim, Orly Weinreb

12. Exercise in Multiple Sclerosis – An Integral Component of Disease Management
Andrea Döring, Caspar F. Pfueller, Friedemann Paul, Jan Dörr

13. Bridging the Informatics Gap Between Bench and Bedside: Implications to Neurodegenerative Diseases
Amnon Shabo (Shvo), Maurizio Scarpa

14. Personalized Medicine in Rare Pediatric Neurometabolic Diseases
Rosella Tomanin, Cinzia Maria Bellettato, Francesca D’Avanzo, Alessandra Zanetti, Adriana Ceci, David Begley, Maurizio Scarpa

Nyckelord: Biomedicine, Biomedicine general, Health Promotion and Disease Prevention, Neurology, Neurosciences