From Molecular to Modular Tumor Therapy:

1. Bridging Theory and Therapeutic Practice: From Generalized Disease Models to Particular Patients
Albrecht Reichle

2. Tumor Systems Need to be Rendered Usable for a New Action-Theoretical Abstraction: The Starting Point for Novel Therapeutic Options
Albrecht Reichle

3. Principles of Modular Tumor Therapy
Albrecht Reichle, Gerhard C. Hildebrandt

4. Cancer and Coagulation; Focusing on Tissue Factor and Heparanase
Yona Nadir

5. The Role of Mesenchymal Cells in Cancer: Contribution to Tumor Stroma and Tumorigenic Capacity
Ofer Shoshani, Dov Zipori

6. Shaping Tumor Associated Macrophages: The Role of NF-κB
Robin Soper, Thorsten Hagemann

7. The Metabolic Achilles Heel: Tumor Cell Metabolism as Therapeutic Target
Eva Gottfried, Katrin Peter, Marina P. Kreutz

8. Could Be Systems-Directed Therapy Approaches Promising in Glioblastoma Patients?
Oliver Grauer, Peter Hau

9. Functional Impacts of Signal Integration: Regulation of Inflammation-Related Transcription Factors by Heterotrimeric G Proteins
Wendy Wing Shan Yeung, Maurice Kwok Chung Ho, Yung Hou Wong

10. Molecular Cross-Talk Between Nuclear Receptors and Nuclear Factor-κB
Ilse M. E. Beck, Guy Haegeman, Karolien Bosscher

11. The Biomodulatory Capacities of Low-Dose Metronomic Chemotherapy: Complex Modulation of the Tumor Microenvironment
Urban Emmenegger, Annabelle Chow, Guido Bocci

12. Systems Biology: A Therapeutic Target for Tumor Therapy
Albrecht Reichle, Thomas Vogt

13. The Comparative Uncovering of Tumor Systems Biology by Modularly Targeting Tumor-Associated Inflammation
Albrecht Reichle, Gerhard C. Hildebrandt

14. Searching for the ‘Metabolism’ of Evolution
Albrecht Reichle, Gerhard C. Hildebrand

15. The Impact of Inflammation Control and Active Cancer Palliation on Metabolic Pathways Determining Tumor Progression and Patient Survival
Ulrika Smedh, Annika Gustafsson, Hans Axelsson, Christian Cahlin, Christina Lönnroth, Kent Lundholm

16. Pioglitazone and Rofecoxib Combined with Angiostatically Scheduled Capecitabine in Far-Advanced Hepatobiliary Carcinoma
Albrecht Reichle, Frank Klebl, Klaus Bross, Frank Kullmann, Peter Wild, Anna Berand, Stefan W. Krause, Jürgen Schölmerich, Reinhard Andreesen

17. C-Reactive Protein As a Secretome-Derived Biomarker for Predicting Response to Biomodulatory Therapy in Metastatic Renal Clear Cell Carcinoma
Bernhard Walter, Irmela Schrettenbrunner, Martin Vogelhuber, Jochen Grassinger, Klaus Bross, Jochen Wilke, Thomas Suedhoff, Anna Berand, Wolf-Ferdinand Wieland, Sebastian Rogenhofer, Albrecht Reichle

18. Modular Therapy Approach in Metastatic Castration-Resistent Prostate Cancer
Bernhard Walter, Sebastian Rogenhofer, Martin Vogelhuber, Jochen Wilke, Anna Berand, Walter Ferdinand Wieland, Reinhard Andreesen, Albrecht Reichle

19. Systems-Directed Therapy in Metastatic Castration-Resistent Prostate Cancer (CRCP)
Albrecht Reichle, Martin Vogelhuber, Anna Berand, Reinhard Andreesen, Irene Fackler-Schwalbe, Annemarie Rübel, Thomas Südhoff

20. Early Detection of Systems Response: Molecular and Functional Imaging of Angiogenesis
Fabian Kiessling, Wiltrud Lederle

21. Secretome Proteomics, a Novel Tool for Biomarkers Discovery and for Guiding Biomodulatory Therapy Approaches
Verena Paulitschke, Rainer Kunstfeld, Christopher Gerner

22. Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma
Stefanie Meyer, Thomas Vogt, Michael Landthaler, Anna Berand, Albrecht Reichle, Frauke Bataille, Andreas Marx, Guido Sauter, Arndt Hartmann, Leoni Kunz-Schughart, Peter J. Wild

23. Uncovering Tumor Systems Biology by Biomodulatory Therapy Strategies
Albrecht Reichle

24. Breathing New Life into Old Drugs: Indication Discovery by Systems Directed Therapy
Annika Bundscherer, Christian Hafner

25. A Methodological Approach to Personalized Therapies in Metastatic Cancer
Albrecht Reichle, Thomas Vogt, Gerhard C. Hildebrandt

26. To Be an Object in a Biological System
Albrecht Reichle, Gerhard C. Hildebrandt

27. From Molecular to Modular, from Theme-Dependent to Evolution-Adjusted Tumor Therapy
Albrecht Reichle, Gerhard C. Hildebrandt

Nyckelord: Biomedicine, Cancer Research, Pharmaceutical Sciences/Technology, Evolutionary Biology, Systems Biology, Medicine/Public Health, general, Theory of Medicine/Bioethics