Genome Stability and Human Diseases

1. Coming Full Circle: Cyclin-Dependent Kinases as Anti-cancer Drug Targets
Robert P. Fisher

2. Core and Linker Histone Modifications Involved in the DNA Damage Response
Jennifer E. Chubb, Stephen Rea

3. Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56
Thomas Costelloe, Noel F. Lowndes

4. Structure and Function of Histone H2AX
David Miguel Susano Pinto, Andrew Flaus

5. The Initiation Step of Eukaryotic DNA Replication
Helmut Pospiech, Frank Grosse, Francesca M. Pisani

6. Non-coding RNAs: New Players in the Field of Eukaryotic DNA Replication
Torsten Krude

7. Function of TopBP1 in Genome Stability
Miiko Sokka, Sinikka Parkkinen, Helmut Pospiech, Juhani E. Syväoja

8. Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability
Sandra Broderick, Kristina Rehmet, Claire Concannon, Heinz-Peter Nasheuer

9. DNA Polymerases and Mutagenesis in Human Cancers
Emmanuele Crespan, Alessandra Amoroso, Giovanni Maga

10. DNA Polymerase η, a Key Protein in Translesion Synthesis in Human Cells
Séverine Cruet-Hennequart, Kathleen Gallagher, Anna M. Sokòl, Sangamitra Villalan, Áine M. Prendergast, Michael P. Carty

11. The Mitochondrial DNA Polymerase in Health and Disease
William C. Copeland

12. Centromeres: Assembling and Propagating Epigenetic Function
Macdara Glynn, Agnieszka Kaczmarczyk, Lisa Prendergast, Nadine Quinn, Kevin F. Sullivan

13. Nucleotide Excision Repair in Higher Eukaryotes: Mechanism of Primary Damage Recognition in Global Genome Repair
N.I. Rechkunova, O.I. Lavrik

14. Nonhomologous DNA End Joining (NHEJ) and Chromosomal Translocations in Humans
Michael R. Lieber, Jiafeng Gu, Haihui Lu, Noriko Shimazaki, Albert G. Tsai

15. Fluorescence-Based Quantification of Pathway-Specific DNA Double-Strand Break Repair Activities: A Powerful Method for the Analysis of Genome Destabilizing Mechanisms
Michael Böhringer, Lisa Wiesmüller

16. Apoptosis: A Way to Maintain Healthy Individuals
Chiara Mondello, A. Ivana Scovassi

17. The Use of Transgenic Mice in Cancer and Genome Stability Research
Sarah Conmy, Heinz-Peter Nasheuer

Nyckelord: Biomedicine, Human Genetics, Cytogenetics, Cancer Research, Laboratory Medicine, Cell Biology