HCV Infection and Cryoglobulinemia

1. Introductory Remarks
Franco Dammacco, Domenico Sansonno

2. Natural History, Pathogenesis, and Prevention of HCV Infection
Edgar D. Charles, Lynn B. Dustin, Charles M. Rice

3. Immune Control of HCV Infection
Lynn B. Dustin

4. B Cell Activation: General to HCV-Specific Considerations
Vito Racanelli, Claudia Brunetti

5. Organ-Specific Autoimmunity in HCV-Positive Patients
Corrado Betterle, Fabio Presotto

6. HCV and Blood Cells: How Can We Distinguish Infection from Association?
Lynn B. Dustin, Charles M. Rice

7. Mechanisms of Cell Entry of Hepatitis C Virus
Franco Dammacco, Vito Racanelli

8. HCV Infection of Hematopoietic and Immune Cell Subsets
Tram N. Q. Pham, Tomasz I. Michalak

9. Cryoglobulinemia and Chronic HCV Infection: An Evolving Story
Jürg A. Schifferli, Marten Trendelenburg

10. The Complement System in Cryoglobulinemia
Marten Trendelenburg

11. The Pivotal Role of C1qR in Mixed Cryoglobulinemia
Domenico Sansonno, Loredana Sansonno, Franco Dammacco

12. Mixed Cryoglobulinemia (MC) Cross-Reactive Idiotypes (CRI): Structural and Clinical Significance
Peter D. Gorevic

13. Molecular Insights into the Disease Mechanisms of Type II Mixed Cryoglobulinemia
Valli Re, Marica Garziera

14. The Role of VCAM-1 in the Pathogenesis of Hepatitis-C-Associated Mixed Cryoglobulinemia Vasculitis
Gilles Kaplanski

15. Up-Regulation of B-Lymphocyte Stimulator (BLyS) in Patients with Mixed Cryoglobulinemia
Martina Fabris, Salvatore Vita

16. Role of B-Cell-Attracting Chemokine-1 in HCV-Related Cryoglobulinemic Vasculitis
Sabino Russi, Silvia Sansonno, Gianfranco Lauletta, Domenico E. Sansonno, Franco Dammacco

17. Serum α-Chemokine CXCL10 and β-Chemokine CCL2 Levels in HCV-Positive Cryoglobulinemia
Alessandro Antonelli, Clodoveo Ferri, Silvia Martina Ferrari, Michele Colaci, Ilaria Ruffilli, Caterina Mancusi, Ele Ferrannini, Poupak Fallahi

18. Experimental Models of Mixed Cryoglobulinemia
Charles E. Alpers, Tomasz A. Wietecha, Kelly L. Hudkins

19. The Expanding Spectrum of Clinical Features in HCV-Related Mixed Cryoglobulinemia
Clodoveo Ferri, Alessandro Antonelli, Marco Sebastiani, Michele Colaci, Anna Linda Zignego

20. Classification of Cryoglobulinemic Vasculitis
Salvatore Vita, Luca Quartuccio

21. Demographic and Survival Studies of Cryoglobulinemic Patients
Giuseppe Monti, Francesco Saccardo, Laura Castelnovo

22. HCV-Associated Membranoproliferative Glomerulonephritis
Christos P. Argyropoulos, Sheldon Bastacky, John Prentiss Johnson

23. Rheumatologic Symptoms in Patients with Mixed Cryoglobulinemia
Gianfranco Ferraccioli, Francesca Faustini, Elisa Gremese

24. Endocrine Manifestations of HCV-Positive Cryoglobulinemia
Alessandro Antonelli, Clodoveo Ferri, Silvia Martina Ferrari, Michele Colaci, Alda Corrado, Andrea Domenicantonio, Poupak Fallahi

25. Cutaneous Cryoglobulinemic Vasculitis
Konstantinos Linos, Bernard Cribier, J. Andrew Carlson

26. Peripheral Neuropathy and Central Nervous System Involvement in Cryoglobulinemia
Salvatore Monaco, Sara Mariotto, Sergio Ferrari

27. Long-Term Course of Patients with Mixed Cryoglobulinemia
Damien Sene, Patrice P. Cacoub

28. HBV/HCV Co-infection and Mixed Cryoglobulinemia
Massimo Galli, Salvatore Sollima

29. Clinical and Immunological Features of HCV/HIV Co-infected Patients with Mixed Cryoglobulinemia
David Saadoun, Patrice P. Cacoub

30. HCV-Negative Mixed Cryoglobulinemia: Facts and Fancies
Massimo Galli, Salvatore Sollima, Giuseppe Monti

31. Cryoglobulinemia in HCV-Positive Renal Transplant and Liver Transplant Patients
Lionel Rostaing, Hugo Weclawiak, Nassim Kamar

32. Chromosome Abnormalities in HCV-Related Lymphoproliferation
Cristina Mecucci, Gianluca Barba, Caterina Matteucci

33. Molecular Features of Lymphoproliferation in Mixed Cryoglobulinemia
Valli Re, Maria Paola Simula

34. The Higher Prevalence of B-Cell Non-Hodgkin’s Lymphoma in HCV-Positive Patients with and Without Cryoglobulinemia
Franco Dammacco, Domenico Sansonno

35. Incidence and Characteristics of Non-Hodgkin’s Lymphomas in HCV-Positive Patients with Mixed Cryoglobulinemia
Pietro Enrico Pioltelli, Giuseppe Monti, Maurizio Pietrogrande, Massimo Galli

36. Waldenström’s Macroglobulinemia Associated with Cryoglobulinemia: Pathogenetic, Clinical, and Therapeutic Aspects
Meletios A. Dimopoulos, Efstathios Kastritis

37. Should HCV-Positive Asymptomatic Patients with Mixed Cryoglobulinemia Be Treated with Combined Antiviral Therapy?
José Luis Calleja Panero, Juan Negro, Fernando Pons Renedo

38. The Role of Rituximab in the Therapy of Mixed Cryoglobulinemia
Francesco Zaja, Stefano Volpetti, Stefano Luca, Renato Fanin

39. Rituximab in Cryoglobulinemic Vasculitis: First- or Second-Line Therapy?
Peter Lamprecht, Paul Klenerman

40. PIRR Therapy in HCV-Related Mixed Cryoglobulinemia
Franco Dammacco, Domenico Sansonno

41. Antiviral Therapy in HCV-Positive Non-Hodgkin’s Lymphoma: Pathogenetic Implications
Franco Dammacco, Cinzia Conteduca, Domenico Sansonno

42. Active or Indolent Cutaneous Ulcers in Cryoglobulinemia: How Should They Be Treated?
Maurizio Pietrogrande

43. Double Filtration Plasmapheresis: An Effective Treatment of Cryoglobulinemia
Alfonso Ramunni, Paola Brescia

44. Emergency in Cryoglobulinemia: Clinical and Therapeutic Approach
Francesco Saccardo, Laura Castelnovo, Giuseppe Monti

45. Novel Therapeutic Approaches to Cryoglobulinemia: Imatinib, Infliximab, Bortezomib, and Beyond
Giampaolo Talamo, Maurizio Zangari

Nyckelord: Medicine & Public Health, Hepatology, Internal Medicine, Infectious Diseases, Rheumatology, Oncology