Molecular Imaging for Integrated Medical Therapy and Drug Development

1. Advances in Molecular Imaging
Nagara Tamaki, Yuji Kuge

Part I. New Molecular Imaging and Image-Guided Radiotherapy

2. Hypoxia Imaging for Image-Guided Radiotherapy
Quynh-Thu Le, Billy W. Loo, Nancy Lee

3. Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy
Yuji Kuge, Songji Zhao, Toshiki Takei, Nagara Tamaki

4. Development of a Prototype 3D PET Scanner Using Semiconductor Detectors and Depth of Interaction Information
Yuichi Morimoto, Yuichirou Ueno, Shinichi Kojima, Wataru Takeuchi, Takafumi Ishitsu, Kazuki Matsuzaki, Kikuo Umegaki, Naoki Kubo, Chietsugu Katoh, Songji. Zhao, Tohru Shiga, Nagara Tamaki

5. A New PET Scanner with Semiconductor Detector Reveals Intratumoral Inhomogeneous Cell Activity with High Spatial and Energy Resolution
Tohru Shiga, Naoki Kubo, Yuichi Morimoto, Norio Katoh, Chietsugu Katoh, Yuichirou Ueno, Kenji Hirata, Reiko Usui, Keiji Kobayashi, Wataru Takeuchi, Hiroki Shirato, Nagara Tamaki

6. A New Positron Emission Tomography (PET) Scanner with Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients with Nasopharyngeal Carcinoma
Norio Katoh, Koichi Yasuda, Tohru Shiga, Masakaxu Hasegawa, Rikiya Onimaru, Shinichi Shimizu, Gerard Bengua, Masayori Ishikawa, Nagara Tamaki, Hiroki Shirato

7. Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small-Animal Imaging
Keiichi Magota, Naoki Kubo, Kenji Narihiro, Kotaro Suzuki, Kenichi Nishijima, Songji Zhao, Yuji Kuge, Nagara Tamaki

8. Molecular Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG and 99mTc-Annexin A5
Yan Zhao, Yuji Kuge, Songji Zhao, H. William Strauss, Francis G. Blankenberg, Nagara Tamaki

9. Quantification of Myocardial Blood Flow Using Rubidium-82 PET
Keiichiro Yoshinaga, Chietsugu Katoh, Osamu Manabe, Masanao Naya, Robert A. deKemp, Ran Klein, Rob S. B. Beanlands, Nagara Tamaki

Part II. Molecular Imaging for Regenerative Treatment

10. New Concepts for Molecular and Functional Imaging of the Heart: Implications for Regenerative Treatments
Ignasi Carrió, Manel Ballester, Albert Flotats

11. Molecular Imaging of Angiogenesis
Ambros J. Beer, Hans-Jürgen Wester, Markus Schwaiger

12. Spontaneous In Vivo Regeneration of the Articular Cartilage Using a Novel Double-Network Hydrogel
Nobuto Kitamura, Kazunori Yasuda, Jian Ping Gong, Yoshihito Osada

13. Bone Marrow Stromal Cell Transplantation for Central Nervous System Disorders: Perspectives for Translational Research and Clinical Application
Satoshi Kuroda, Yuji Kuge, Nagara Tamaki, Yoshinobu Iwasaki

14. Noninvasive Optical Tracking of Bone Marrow Stromal Cells Transplanted into Rat Cerebral Infarct
Taku Sugiyama, Satoshi Kuroda, Toshiya Osanai, Katsuhiko Maruichi, Yasuhiro Chiba, Hideo Shichinohe, Yuji Kuge, Nagara Tamaki, Yoshinobu Iwasaki

15. Thermoreversible Gelation Polymer (TGP) Hydrogel as a Degradable Scaffold for Bone Marrow Stromal Cell Transplantation
Toshiya Osanai, Satoshi Kuroda, Hiroshi Yasuda, Yasuhiro Chiba, Katsuhiko Maruichi, Masaaki Hokari, Taku Sugiyama, Hideo Shichinohe, Yoshinobu Iwasaki

16. Beneficial Effects of Bone Marrow Stromal Cell Transplantation on Axonal Regeneration in Injured Spinal Cord
Yasuhiro Chiba, Satoshi Kuroda, Katsuhiko Maruichi, Toshiya Osanai, Masaaki Hokari, Shunsuke Yano, Hideo Shichinohe, Kazutoshi Hida, Yoshinobu Iwasaki

17. Transplanted Bone Marrow Stromal Cells Improve Cognitive Function after Diffuse Axonal Injury in Rats
Katsuhiko Maruichi, Satoshi Kuroda, Yasuhiro Chiba, Toshiya Osanai, Taku Sugiyama, Masaaki Hokari, Kazutoshi Hida, Yoshinobu Iwasaki

Part III. Molecular Imaging and Future Perspectives of Brain Research

18. Ultra-High Throughput Screening (uHTS) Chemical Genetics to Identify Novel Chronotherapeutics
Steve A. Kay, Tsuyoshi Hirota

19. Cell Death and Autophagy
Yasuo Uchiyama, Masato Koike, Masahiro Shibata

20. Bioluminescent Imaging for Assessing Heterogeneous Cell Functions in the Mammalian Central Circadian Clock
Sato Honma, Tomoko Yoshikawa, Shin-ya Nishide, Daisuke Ono, Ken-ichi Honma

21. Early Postnatal Stress and the Serotonergic System in the Brain
Kohtarou Konno, Mitsuhiro Yoshioka

22. Neural Circuit Development and Plasticity Shaped by Glutamate Transporters
Taisuke Miyazaki, Chihiro Takasaki, Masahiko Watanabe

23. Molecular and Functional Imaging for Drug Development and Elucidation of Disease Mechanisms Using Positron Emission Tomography (PET)
Manabu Tashiro, Toshihiko Fujimoto, Nobuyuki Okamura, Ren Iwata, Hiroshi Fukuda, Kazuhiko Yanai

Part IV. Recent Trends in Drug Developments

24. The Sea as a Source of New Drugs
Fernando Albericio, Mercedes Álvarez, Carmen Cuevas, Andres Francesch, Daniel Pla, Judit Tulla-Puche

25. PET/AMS Applications in Drug Development
Tomio Inoue, Akiko Suzuki, Ryogo Minamimoto

26. Functional and Structural Analysis Reveals Dual Function on C-Terminal α Helix of Alg13 Protein
Xiao-Dong Gao, Satoru Moriyama, Nobuaki Miura, Shin-Ichiro Nishimura

27. Discovery of a First-in-Class Drug, a Prostaglandin D2 Antagonist, for the Treatment of Allergic Diseases
Akinori Arimura

28. Towards Developing a Golgi Simulator: Microfluidic Device Enabling Synthesis of a Tetrasaccharide
Yasunari Ono, Shusaku Daikoku, Yasuko Hasegawa, Toshiyuki Sato, Mariko Kobayashi, Katsuhiko Suzuki, Osamu Kanie

29. An Efficient Strategy for the Exploration of Specific Inhibitors of Sialyltransferases
Kensaku Hosoguchi, Takahiro Maeda, Jun-ichi Furukawa, Hiroshi Hinou, Shin-Ichiro Nishimura

Nyckelord: Medicine & Public Health, Imaging / Radiology