Paroxysmal Nocturnal Hemoglobinuria

1. A History of Research of PNH: Defining a Disease
Wendell Franklyn Rosse

Part I. Basic Sciences in PNH

2. Synthesis, Genetics, and Congenital Diseases of GPI-Anchored Proteins
Yusuke Maeda, Yoshiko Murakami, Taroh Kinoshita

3. Animal Models of Paroxysmal Nocturnal Hemoglobinuria
Yoshiko Murakami, Taroh Kinoshita

4. Complement and PNH
Charles J. Parker

Part II. Clinical Sciences in PNH

5. Epidemiology in PNH: The PNH Global Registry
Robert A. Brodsky

6. Epidemiology in PNH: Clinical Epidemiological Studies in Korea
Jong Wook Lee

7. Haemolysis in PNH: Depletion of Nitric Oxide
Anita Hill

8. Bone Marrow Failure in PNH
Britta Höchsmann, Hubert Schrezenmeier

9. Thrombophilia in PNH
Haruhiko Ninomiya, Anita Hill

10. Diagnosis and Classification of PNH
Hideki Nakakuma, Tsutomu Shichishima, Jun-ichi Nishimura

11. Clinical Significance of a Small Population of Glycosylphosphatidylinositol-Anchored Membrane Proteins (GPI-APs)-Deficient Cells in the Management of Bone Marrow Failure
Shinji Nakao

12. Clonal Origin and Clonal Selection in PNH
Lucio Luzzatto

13. Pathogenesis of Clonal Dominance in PNH: Selection Mechanisms in PNH
Tatsuya Kawaguchi, Hideki Nakakuma

14. Pathogenesis of Clonal Dominance in PNH: Growth Advantage in PNH
Norimitsu Inoue, Taroh Kinoshita

15. Clinical Management in PNH
Tsutomu Shichishima, Hideyoshi Noji

16. Clinical Effects of Eculizumab in PNH
Jeffrey Szer

17. Clinical Effects of Eculizumab in PNH: Extravascular Hemolysis After Eculizumab Treatment
Rosario Notaro, Antonio M. Risitano

18. Clinical Effects of Eculizumab in PNH: Poor Responders to Eculizumab
Jun-ichi Nishimura, Taroh Kinoshita, Yuzuru Kanakura

19. Hematopoietic Stem Cell Transplantation in PNH
Gérard Socié, Régis Peffault Latour

20. Future Strategies of Complement Inhibition in Paroxysmal Nocturnal Hemoglobinuria
Antonio M. Risitano

21. Pregnancy in Paroxysmal Nocturnal Hemoglobinuria
Naoyuki Miyasaka, Osamu Miura

Nyckelord: Medicine & Public Health, Hematology, Immunology