Regulatory Mechanisms of Striated Muscle Contraction

I.Historical Aspects

1. Biological Actions of Calcium
Andrew Fielding Huxley

2. Professor Ebashi’s Journey Toward the Discovery of Troponin: A Personal Recollection
Makoto Endo

3. Highlights of the History of Calcium Regulation of Striated Muscle
John Gergely

II.Regulation by Troponin and Tropomyosin

4. Troponin: Structure, Function and Dysfunction
Iwao Ohtsuki

5. From the Crystal Structure of Troponin to the Mechanism of Calcium Regulation of Muscle Contraction
Yuichiro Maeda, Yasushi Nitanai, Toshiro Oda

6. Ca Ion and the Troponin Switch
Maia V. Vinogradova, Deborah B. Stone, Galina G. Malanina, Robert A. Mendelson, Robert J. Fletterick

7. Disposition and Dynamics: Interdomain Orientations in Troponin
Ryan M. B. Hoffman, Brian D. Sykes

8. Structural Basis for Calcium-Regulated Relaxation of Striated Muscles at Interaction Sites of Troponin with Actin and Tropomyosin
Kenji Murakami, Fumiaki Yumoto, Shin-ya Ohki, Takuo Yasunaga, Masaru Tanokura, Takeyuki Wakabayashi

9. Tropomyosin: Regulator of Actin Filaments
Sarah E. Hitchcock-DeGregori, Norma J. Greenfield, Abhishek Singh

10. Tropomyosin and Troponin Cooperativity on the Thin Filament
Sabrina E. Boussouf, Michael A. Geeves

11. Conformational Changes in Reconstituted Skeletal Muscle Thin Filaments Observed by Fluorescence Spectroscopy
Masao Miki

12. Calcium Structural Transition of Troponin in the Complexes, on the Thin Filament, and in Muscle Fibres, as Studied By Site-Directed Spin-Labelling EPR
Toshiaki Arata, Tomoki Aihara, Keisuke Ueda, Motoyoshi Nakamura, Shoji Ueki

13. Crystal Structures of Tropomyosin: Flexible Coiled-Coil
Yasushi Nitanai, Shiho Minakata, Kayo Maeda, Naoko Oda, Yuichiro Maéda

14. C. Elegans Model for Studying Tropomyosin and Troponin Regulations of Muscle Contraction and Animal Behavior
Hiroaki Kagawa, Tomohide Takaya, Razia Ruksana, Frederick Anokye-Danso, Md. Ziaul Amin, Hiromi Terami

15. Structural and Functional Analysis of Troponins from Scallop Striated and Human Cardiac Muscles
Fumiaki Yumoto, Masaru Tanokura

III.Regulation in Cardiac Muscle and Disorders

16. Cooperativity in the Regulation of Force and the Kinetics of Force Development in Heart and Skeletal Muscles
Daniel P. Fitzsimons, Richard L. Moss

17. Heart Failure, Ischemia/Reperfusion Injury and Cardiac Troponin
R. John Solaro, Grace M. Arteaga

18. Troponin Mutations in Cardiomyopathies
Jens Mogensen

19. Molecular Pathogenic Mechanisms of Cardiomyopathies Caused by Mutations in Cardiac Troponin T
Sachio Morimoto

20. Cardiac Troponin Levels as a Preferable Biomarker of Myocardial Cell Degradation
Teruhiko Toyo-oka, Hiroyuki Kumagai

IV.Regulation by Myosin

21. Regulation by Myosin: How Calcium Regulates Some Myosins, Past and Present
Andrew G. Szent-Györgyi

22. Calcium Inhibition of Physarum Myosin as Examined by the Recombinant Heavy Mero-Myosin
Hozumi Kawamichi, Ying Zhang, Mizuki Hino, Akio Nakamura, Hideyuki Tanaka, Lászlo Farkas, Lászlo Nyitray, Kazuhiro Kohama

V.Excitation-Contraction Coupling and Disorder

23. Calcium-Induced Release of Calcium From the Sarcoplasmic Reticulum
Makoto Endo

24. Dysregulation of the Gain of CICR Through Ryanodine Receptor1 (RyR1): The Putative Mechanism Underlying Malignant Hyperthermia
Yasuo Ogawa

25. Ion Pumping by Calcium ATPase of Sarcoplasmic Reticulum
Chikashi Toyoshima

26. Regulation of Cell Functions by Ca2+ Oscillation
Masamitsu Iino

VI.Molecular Mechanisms of Muscle Contraction

27. Evidence About the Structural Behaviour of Myosin Crossbridges During Muscle Contraction
Hugh E. Huxley

28. Structural Alterations of Thin Actin Filaments in Muscle Contraction by Synchrotron X-ray Fiber Diffraction
Katsuzo Wakabayashi, Yasunobu Sugimoto, Yasunori Takezawa, Yutaka Ueno, Shiho Minakata, Kanji Oshima, Tatsuhito Matsuo, Takakazu Kobayashi

29. Regulation of Muscle Contraction by Ca2+ and ADP: Focusing on the0 Auto-Oscillation (SPOC)
Shin’ichi Ishiwata, Yuta Shimamoto, Madoka Suzuki, Daisuke Sasaki

30. Muscle Contraction Mechanism Based on Actin Filament Rotation
Toshio Yanagida

31. On the Walking Mechanism of Linear Molecular Motors
Kazuhiko Kinosita, Katsuyuki Shiroguchi, M. Yusuf Ali, Kengo Adachi, Hiroyasu Itoh

32. Modeling of the F-Actin Structure
Toshiro Oda, Heiko Stegmann, Rasmus R. Schröder, Keiichi Namba, Yuichiro Maéda

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Nyckelord: TECHNOLOGY & ENGINEERING / Biomedical TEC059000