New Therapeutic Targets in Rheumatoid Arthritis

1. B cell targets in rheumatoid arthritis
Edward M. Vital, Shouvik Dass, Paul Emery

2. Co-stimulatory pathways in the therapy of rheumatoid arthritis
Eric M. Ruderman, Richard M. Pope

3. Immunobiology of IL-6 — Tocilizumab (humanised anti-IL-6 receptor antibody) for the treatment of rheumatoid arthritis
Yoshiyuki Ohsugi, Tadamitsu Kishimoto

4. Role of IL-1 in erosive arthritis, lessons from animal models
Wim B. Berg, Leo A. B. Joosten, Fons A. J. Loo

5. Interleukin-15
Jagtar Nijar Singh, Iain B. McInnes

6. IL-17 and Th17 cells, key players in arthritis
Pierre Miossec, Ling Toh, Saloua Zrioual

7. Role of IL-18 in inflammatory diseases
Charles A. Dinarello

8. Chemokines and chemokine receptors
Zoltán Szekanecz, Alisa E. Koch

9. Signaling pathways in rheumatoid arthritis
Jean-Marc Waldburger, Gary S. Firestein

10. Targeting oncostatin M in the treatment of rheumatoid arthritis
Theresa C. Barnes, Robert J. Moots

11. Targeting the epigenetic modifications of synovial cells
Lars C. Huber, Astrid Jüngel, Steffen Gay

12. Perspectives in targeted therapy
Edward C. Keystone

Nyckelord: Medicine & Public Health, Rheumatology, Immunology, Pharmacology/Toxicology, Cell Biology