High-Risk Cutaneous Squamous Cell Carcinoma

Part I. Defining the Problem of High-Risk SCC

1. Epidemiology and Outcomes of Cutaneous Squamous Cell Carcinoma
Pritesh S. Karia

2. Tumor Staging Systems and Prognostic Stratification
Anokhi Jambusaria-Pahlajani

Part II. The Science of SCC

3. Genomics of SCC: Tumor Formation, Progression, and Future Therapeutic Implications for High-Risk Cutaneous Squamous Cell Carcinoma
Catherine Anne Harwood, Charlotte Mary Proby, Sarah Tuttleton Arron

4. Molecular and Cellular Interplay in SCC Including Immunomodulation and Clinical Implications
Valerie Yanofsky, John A. Carucci, Günther F. L. Hofbauer

Part III. Management of High-Risk SCC

5. Management of Patients with Multiple SCCs/Field Cancerization
Sasha Jenkins Haberle, Lauren Rimoin, Myrto Georgia Trakatelli, Fiona Zwald

6. Management of High-Risk Primary Tumors Including Nodal Staging
Vishal Anil Patel, Christian L. Baum, Désirée Ratner

7. Management of Local Recurrence and In-Transit Metastasis
Vitaly Terushkin, John A. Carucci

8. Management of Nodal Metastases
Michael Veness, Julie Howle

9. Management of Widely Metastatic and Unresectable Cutaneous Squamous Cell Carcinoma
Glenn J. Hanna, Emily Stamell Ruiz, Jochen H. Lorch

10. Immune Dysfunction and Immunosuppression: Impacts on SCC Incidence, Prognosis, and Management
Travis W. Blalock, Thomas Stasko

Nyckelord: Medicine & Public Health, Dermatology, Oncology