Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

Part I. Virology, Pathogenesis, and Clinical and Epidemiological Features of Disease

1. Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease
Peter L. Collins, Rachel Fearns, Barney S. Graham

2. Clinical and Epidemiologic Features of Respiratory Syncytial Virus
Caroline B. Hall, Eric A. F. Simőes, Larry J. Anderson

3. Influence of Respiratory Syncytial Virus Strain Differences on Pathogenesis and Immunity
José A. Melero, Martin L. Moore

4. Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins
Jason S. McLellan, William C. Ray, Mark E. Peeples

5. Respiratory Syncytial Virus and Reactive Airway Disease
Matthew T. Lotz, Martin L. Moore, R. Stokes Peebles

Part II. Host Response to Infection and Genetics of Disease

6. Human Genetics and Respiratory Syncytial Virus Disease: Current Findings and Future Approaches
Eun Hwa Choi, Hoan Jong Lee, Stephen J. Chanock

7. Innate Immune Responses to Respiratory Syncytial Virus Infection
Sumanta Mukherjee, Nicholas W. Lukacs

8. The Adaptive Immune Response to Respiratory Syncytial Virus
Steven M. Varga, Thomas J. Braciale

9. Respiratory Syncytial Virus Mechanisms to Interfere with Type 1 Interferons
Sailen Barik

10. Host Gene Expression and Respiratory Syncytial Virus Infection
Ralph A. Tripp, Asuncion Mejias, Octavio Ramilo

11. Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus
Allison M. W. Malloy, Ann R. Falsey, Tracy J. Ruckwardt

Part III. Vaccine Platforms and Treatment Options

12. Respiratory Syncytial Virus Disease: Prevention and Treatment
Helen Y. Chu, Janet A. Englund

13. Live-Attenuated Respiratory Syncytial Virus Vaccines
Ruth A. Karron, Ursula J. Buchholz, Peter L. Collins

14. Subunit and Virus-Like Particle Vaccine Approaches for Respiratory Syncytial Virus
Trudy G. Morrison, Edward E. Walsh

15. Gene-Based Vaccine Approaches for Respiratory Syncytial Virus
Rebecca J. Loomis, Philip R. Johnson

Part IV. Animal and Tissue Culture Models of Infection

16. Bovine Model of Respiratory Syncytial Virus Infection
Geraldine Taylor

17. The Cotton Rat Sigmodon Hispidus Model of Respiratory Syncytial Virus Infection
Marina S. Boukhvalova, Jorge C. G. Blanco

18. The Mouse Model of Respiratory Syncytial Virus Disease
Peter J. Openshaw

19. Human Airway Epithelial Cell Cultures for Modeling Respiratory Syncytial Virus Infection
Raymond J. Pickles

Part V. Conclusions

20. Challenges and Opportunities for Respiratory Syncytial Virus Vaccines
Barney S. Graham, Larry J. Anderson

Nyckelord: Biomedicine, Virology, Vaccine, Infectious Diseases, Pneumology/Respiratory System, Pediatrics