Pharmacotherapy of Pulmonary Hypertension

Part I. Pulmonary Hypertension: Conceptual Bases of the Disease

1. Definition and Classification of Pulmonary Hypertension
Marc Humbert, David Montani, Oleg V. Evgenov, Gérald Simonneau

2. Pulmonary Hypertension: Pathophysiology and Signaling Pathways
Bradley A. Maron, Joseph Loscalzo

3. Pulmonary Hypertension: Pathology
Peter Dorfmüller

4. Pulmonary Hypertension: Biomarkers
Christopher J. Rhodes, John Wharton, Martin R. Wilkins

5. Rodent Models of Group 1 Pulmonary Hypertension
John J. Ryan, Glenn Marsboom, Stephen L. Archer

Part II. Pulmonary Hypertension: Established Therapies

6. General Supportive Care
Ioana R. Preston

7. Calcium-Channel Blockers in Pulmonary Arterial Hypertension
Marie-Camille Chaumais, Elise Artaud Macari, Olivier Sitbon

8. Prostacyclins
Horst Olschewski

9. Endothelin Receptor Antagonists
Martine Clozel, Alessandro Maresta, Marc Humbert

10. Phosphodiesterase-5 Inhibitors
Barbara A. Cockrill, Aaron B. Waxman

11. Inhaled Nitric Oxide for the Treatment of Pulmonary Arterial Hypertension
Steven H. Abman

Part III. Pulmonary Hypertension: Novel Pathways and Emerging Therapies

12. Soluble Guanylate Cyclase Stimulators in Pulmonary Hypertension
Johannes-Peter Stasch, Oleg V. Evgenov

13. Therapeutics Targeting of Dysregulated Redox Equilibrium and Endothelial Dysfunction
Michael G. Risbano, Mark T. Gladwin

14. Rho-Kinase Inhibitors
Yoshihiro Fukumoto, Hiroaki Shimokawa

15. Serotonin Transporter and Serotonin Receptors
Serge Adnot, Amal Houssaini, Shariq Abid, Elisabeth Marcos, Valérie Amsellem

16. Targeting of Platelet-Derived Growth Factor Signaling in Pulmonary Arterial Hypertension
Eva Berghausen, Henrik Freyhaus, Stephan Rosenkranz

17. Emerging Molecular Targets for Anti-proliferative Strategies in Pulmonary Arterial Hypertension
Ly Tu, Christophe Guignabert

18. Anti-inflammatory and Immunosuppressive Agents in PAH
Jolyane Meloche, Sébastien Renard, Steeve Provencher, Sébastien Bonnet

19. Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application
Reshma S. Baliga, Raymond J. MacAllister, Adrian J. Hobbs

20. Pulmonary Hypertension: Novel Pathways and Emerging Therapies Inhibitors of cGMP and cAMP Metabolism
Yassine Sassi, Jean-Sébastien Hulot

21. Pulmonary Hypertension: Old Targets Revisited (Statins, PPARs, Beta-Blockers)
Geoffrey Watson, Eduardo Oliver, Lan Zhao, Martin R. Wilkins

Part IV. Conclusions and Outlook

22. Pulmonary Hypertension: Current Management and Future Directions
Lewis J. Rubin

Nyckelord: Biomedicine, Pharmacology/Toxicology, Pharmaceutical Sciences/Technology, Internal Medicine, Pneumology/Respiratory System, Laboratory Medicine, Molecular Medicine