Epigenetic Therapy of Cancer

1. The Fundamental Role of Epigenetic Regulation in Normal and Disturbed Cell Growth, Differentiation, and Stemness
Manuel Rodríguez-Paredes, Manel Esteller

2. Mouse Models to Study DNA Methylation in Cancer Research
Irina Savelyeva, Frank Rosenbauer

3. Epigenetic Regulation of Normal Hematopoietic Development
Pratima Chaurasia, Dmitriy Berenzon, Ronald Hoffman

4. Epigenetic Regulation of Globin Genes and Disturbances in Hemoglobinopathies
Yogen Saunthararajah, Donald Lavelle, Joseph DeSimone

5. DNA Methylation Abnormalities in Hematopoietic Disorders: Biological Significance and Methodological Approaches
Rainer Claus, Maximilian Schmutz, Gabriele Greve, Lars Bullinger

6. Epigenetic Modifications Mediated by the AML1/ETO and MLL Leukemia Fusion Proteins
Jesús Duque-Afonso, Michael Lübbert, Michael L. Cleary

7. Treatment of Hematologic Malignancies with DNA Hypomethylating Agents
Michael Daskalakis, Tina E. Joeckel, Michael Lübbert, A. Kuendgen

8. Pharmacodynamic Responses to DNA Methyltransferase Inhibition
Elizabeth Griffiths, Richard L. Momparler, Adam R. Karpf

9. Histone Methyltransferases: Opportunities in Cancer Drug Discovery
Richard Chesworth, Tim J. Wigle, Kevin W. Kuntz, Jesse J. Smith, Victoria M. Richon

10. Histone Deacetylase (HDAC) Inhibitors in Recent Clinical Trials for Cancer Therapy
Kristina Keller, Manfred Jung

11. Clinical Implications of Epigenetic Alterations in Lung Cancer
David S. Schrump

12. Epigenetic Disturbances in Colorectal Cancer
Sarah Derks, Manon Engeland

13. Epigenetic Therapies in Solid Tumours: From Preclinical Models to Clinical Trial Results
Robert Brown, Juliane Steinmann, Janet Graham, Ros Glasspool

Nyckelord: Medicine & Public Health, Oncology, Hematology, Gene Therapy