Heparin - A Century of Progress

1. History of Heparin
T. W. Barrowcliffe

2. Heparin Biosynthesis
Pernilla Carlsson, Lena Kjellén

3. The Anticoagulant and Antithrombotic Mechanisms of Heparin
Elaine Gray, John Hogwood, Barbara Mulloy

4. Standardisation of Unfractionated and Low-Molecular-Weight Heparin
Elaine Gray

5. Structure and Physicochemical Characterisation of Heparin
Barbara Mulloy

6. Case Study: Contamination of Heparin with Oversulfated Chondroitin Sulfate
Edward K. Chess, Shawn Bairstow, Shane Donovan, Karalyn Havel, Peifeng Hu, Richard J. Johnson, Sarah Lee, Jeff McKee, Reagan Miller, Edwin Moore, Mark Nordhaus, Joseph Ray, Christina Szabo, Todd Wielgos

7. Low-Molecular-Weight Heparins: Differential Characterization/Physical Characterization
Marco Guerrini, Antonella Bisio

8. Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity
Zachary Shriver, Ishan Capila, Ganesh Venkataraman, Ram Sasisekharan

9. Heparin in the Prophylaxis and Treatment of Venous Thromboembolism and Other Thrombotic Diseases
Paolo Gresele, Chiara Busti, Gloria Paganelli

10. Adverse Effects of Heparin
S. Alban

11. Neutralization of Heparin Activity
Menaka Pai, Mark A. Crowther

12. Non-anticoagulant Effects of Heparin: An Overview
Rebecca Lever, Clive P. Page

13. Glycosaminoglycan and Chemokine/Growth Factor Interactions
Janis Shute

14. Glycosaminoglycans and Neuroprotection
B. Dudas, K. Semeniken

15. Heparan Sulphate: A Heparin in Miniature
J. T. Gallagher

16. Heparin Mimetics
Deirdre R. Coombe, Warren C. Kett

17. Hyaluronic Acid
Luigi Allegra, Sabrina Della Patrona, Giuseppe Petrigni

18. Semi-synthetic Heparinoids
P. Oreste, G. Zoppetti

19. Heparin-like Entities from Marine Organisms
S. Colliec-Jouault, C. Bavington, C. Delbarre-Ladrat

Nyckelord: Biomedicine, Pharmacology/Toxicology, Molecular Medicine, Pharmaceutical Sciences/Technology, Internal Medicine, Hematology