Phosphoinositide 3-kinase in Health and Disease

1. PI3K: From the Bench to the Clinic and Back
Bart Vanhaesebroeck, Peter K. Vogt, Christian Rommel

2. Oncogenic Mutations of PIK3CA in Human Cancers
Yardena Samuels, Todd Waldman

3. Structural Effects of Oncogenic PI3Kα Mutations
Sandra B. Gabelli, Chuan-Hsiang Huang, Diana Mandelker, Oleg Schmidt-Kittler, Bert Vogelstein, L. Mario Amzel

4. Comparing the Roles of the p110α and p110β Isoforms of PI3K in Signaling and Cancer
Nina Ilić, Thomas M. Roberts

5. Phosphatidylinositol 3-Kinase: The Oncoprotein
Peter K. Vogt, Jonathan R. Hart, Marco Gymnopoulos, Hao Jiang, Sohye Kang, Andreas G. Bader, Li Zhao, Adam Denley

6. AKT Signaling in Physiology and Disease
Krishna M. Vasudevan, Levi A. Garraway

7. Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse
Caterina Nardella, Arkaitz Carracedo, Leonardo Salmena, Pier Paolo Pandolfi

8. PI3K as a Target for Therapy in Haematological Malignancies
Asim Khwaja

9. Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors
Carlos L. Arteaga

10. From the Bench to the Bed Side: PI3K Pathway Inhibitors in Clinical Development
Saveur-Michel Maira, Peter Finan, Carlos Garcia-Echeverria

11. New Inhibitors of the PI3K-Akt-mTOR Pathway: Insights into mTOR Signaling from a New Generation of Tor Kinase Domain Inhibitors (TORKinibs)
Morris E. Feldman, Kevan M. Shokat

12. Small Molecule Inhibitors of the PI3-Kinase Family
Zachary A. Knight

13. Targeting the RTK-PI3K-mTOR Axis in Malignant Glioma: Overcoming Resistance
Qi-Wen Fan, William A. Weiss

Nyckelord: Biomedicine, Cancer Research