Phosphoinositide 3-kinase in Health and Disease

1. Introduction
Tina L. Yuan, Lewis C. Cantley

2. PDK1: The Major Transducer of PI 3-Kinase Actions
José Ramón Bayascas

3. Protein Kinase B (PKB/Akt), a Key Mediator of the PI3K Signaling Pathway
Elisabeth Fayard, Gongda Xue, Arnaud Parcellier, Lana Bozulic, Brian A. Hemmings

4. PI3Ks in Lymphocyte Signaling and Development
Klaus Okkenhaug, David A. Fruman

5. The Regulation of Class IA PI 3-Kinases by Inter-Subunit Interactions
Jonathan M. Backer

6. Phosphoinositide Signalling Pathways in Metabolic Regulation
Lazaros C. Foukas, Dominic J. Withers

7. Role of RAS in the Regulation of PI 3-Kinase
Esther Castellano, Julian Downward

8. More Than Just Kinases: The Scaffolding Function of PI3K
Carlotta Costa, Emilio Hirsch

9. PI3K Signaling in Neutrophils
Phillip T. Hawkins, Len R. Stephens, Sabine Suire, Michael Wilson

10. PI 3-Kinase p110β Regulation of Platelet Integrin αIIbβ3

Shaun P. Jackson, Simone M. Schoenwaelder

11. Regulatory Subunits of Class IA PI3K
David A. Fruman

12. The Neurodevelopmental Implications of PI3K Signaling
Kathryn Waite, Britta J. Eickholt

13. PI3 Kinase Regulation of Skeletal Muscle Hypertrophy and Atrophy
David J. Glass

14. Taking PI3Kδ and PI3Kγ One Step Ahead: Dual Active PI3Kδ/γ Inhibitors for the Treatment of Immune-Mediated Inflammatory Diseases
Christian Rommel

Nyckelord: Biomedicine, Cancer Research, Human Physiology, Molecular Medicine