Death Receptors and Cognate Ligands in Cancer

1. The Role of TNF in Cancer
Harald Wajant

2. Many Checkpoints on the Road to Cell Death:Regulation of Fas–FasL Interactions and Fas
Signaling in Peripheral Immune Responses
Madhu Ramaswamy, Sophia Y. Clel, Anthony C. Cruz, Richard M. Siegel

3. FasL Expression and Reverse Signalling
M. Lettau, M. Paulsen, D. Kabelitz, O. Janssen

4. Impact of TNF-R1 and CD95 Internalization on Apoptotic and Antiapoptotic Signaling

Stefan Schütze, Wulf Schneider-Brachert

5. Ubiquitination and TNFR1 Signaling
Ken-ichi Fujita, Srinivasa M. Srinivasula

6. From Biochemical Principles of Apoptosis Induction by TRAIL to Application in Tumour Therapy

Stefanie M. Cordier, Kerstin Papenfuss, Henning Walczak

7. Therapeutic Targeting of TWEAK/Fn14 in Cancer: Exploiting the Intrinsic Tumor Cell
Killing Capacity of the Pathway
Jennifer S. Michaelson, Linda C. Burkly

8. APRIL in B-cell Malignancies and Autoimmunity
Fiona C. Kimberley, Jan Paul Medema, Michael Hahne

9. Autophagy in Cancer and Chemotherapy
Shida Yousefi, Hans-Uwe Simon

10. Glucocorticoid-Mediated Apoptosis Resistance of Solid Tumors
Ingrid Herr, Markus W. Büchler, Jürgen Mattern

11. Targeting Death-Receptors in Radiation Therapy
Olivier Niemöller, Claus Belka

12. Death Ligands Designed to Kill: Development and Application of Targeted Cancer Therapeutics Based on Proapoptotic TNF Family Ligands

Jeannette Gerspach, Harald Wajant, Klaus Pfizenmaier

Nyckelord: Biomedicine, Cancer Research, Cell Biology, Molecular Medicine, Biochemistry, general, Oncology