Lead-Seeking Approaches

1. Overview of Hit to Lead: The Medicinal Chemist's Role from HTS Retest to Lead Optimization Hand Off
Christopher A. Lipinski

2. High Throughput Screening in the Twenty-First Century
Jeff W. Paslay, John E. Morin, Richard K. Harrison

3. Lead Discovery Using Virtual Screening
Jack Andrew Bikker, Lakshmi S. Narasimhan

4. NMR Spectroscopy in Fragment Based Drug Design
Maurizio Pellecchia

5. Hit Triage: Medicinal Chemistry Strategies to Improve the Odds of Success in Discovery
Kevin D. Freeman-Cook, Daniel W. Kung

6. Lead Identification
John W. Ellingboe, Adam M. Gilbert

Nyckelord: Chemistry, Medicinal Chemistry, Neurosciences, Organic Chemistry