Pediatric Obesity

Part I. The Obesity Epidemic: A Global Perspective

1. Childhood Obesity in theModern Age: Global Trends, Determinants, Complications, and Costs
Michael Freemark

Part II. Hormonal and Metabolic Control of Appetite, Fat Deposition, and Energy Expenditure

2. Central Control of Energy Metabolism and Hypothalamic Obesity
Belma Haliloglu, Abdullah Bereket

3. Gastrointestinal Hormones and theControl of Food Intake and Energy Metabolism
Laura C. Page, Mark D. Miller, David D’Alessio, Jenny Tong

4. The Gut Microbiome and Control of Weight Gain
Anita L. Kozyrskyj, Hein Min Tun, Sarah L. Bridgman

Part III. Adipocyte Development and Function in Obesity and Insulin Resistance

5. White Adipose Tissue Development and Function in Children and Adolescents: Preclinical Models
Pamela Fischer-Posovszky, Julian Roos, Verena Zoller, Martin Wabitsch

6. White Adipose Tissue Accumulation and Dysfunction in Children with Obesity
Antje Körner, Wieland Kiess, Kathrin Landgraf

7. Brown Adipose Tissue and Body Weight Regulation
Michael Freemark, Sheila Collins

Part IV. The Genetics of Childhood Obesity

8. Monogenic Obesity
Marie Pigeyre, David Meyre

9. Syndromic Obesity
Krystal A. Irizarry, Andrea M. Haqq

10. Polygenic Obesity
Anke Hinney, Johanna Giuranna

Part V. Pre- and Peri-natal Determinants of Childhood Obesity

11. Maternal Determinants of Childhood Obesity: Maternal Obesity, Weight Gain and Smoking
Jenna Hollis, Hazel Inskip, Siân Robinson

12. Fetal and Infancy Growth
Ken K. Ong

13. Intrauterine Exposure to Maternal Diabetes and Childhood Obesity
Dana Dabelea, Katherine A. Sauder

14. Endocrine Disruptors as Obesogens
Leonardo Trasande, Bruce Blumberg

Part VI. The Roles of Diet and Energy Expenditure in Obesity Pathogenesis and Complications

15. Early Feeding Practices and Development of Childhood Obesity
Megan H. Pesch, Julie C. Lumeng

16. Dietary Interventions in theTreatment of Paediatric Obesity
Megan L. Gow, Mandy Ho, Natalie B. Lister, Sarah P. Garnett

17. Vegetarian Diets and Pediatric Obesity
Gina Segovia-Siapco, Sarah Jung, Joan Sabaté

18. Energy Expenditure in Children: The Role of NEAT (Non-exercise Activity Thermogenesis)
Lorraine Lanningham-Foster, James A. Levine

Part VII. Metabolic Complications of Childhood Obesity

19. Obesity and theEndocrine System, Part I: Pathogenesis of Weight Gain in Endocrine and Metabolic Disorders
Michael Freemark

20. Obesity and theEndocrine System, Part II: The Effects of Childhood Obesity on Growth and Bone Maturation, Thyroid and Adrenal Function, Sexual Development, and Bone Mineralization
Michael Freemark

21. Metabolomic Signatures and Metabolic Complications in Childhood Obesity
Pinar Gumus Balikcioglu, Christopher B. Newgard

22. Immune Function in Obesity
Yazan Alwarawrah, Nancie J. MacIver

23. Pathogenesis of Insulin Resistance and Glucose Intolerance in Childhood Obesity
Ram Weiss, Emilia Hagman

24. Youth-Onset Type 2 Diabetes
Orit Pinhas-Hamiel, Philip S. Zeitler, Megan M. Kelsey

25. Pathogenesis and Management of Dyslipidemia in Obese Children
Brian W. McCrindle

26. Fatty Liver Disease
Della Corte Claudia, Antonella Mosca, Arianna Alterio, Donatella Comparcola, Francesca Ferretti, Valerio Nobili

27. Pathogenesis of Hypertension and Renal Disease in Obese Children
Tracy E. Hunley, Vance L. Albaugh, Valentina Kon

28. Sleep-Disordered Breathing and Sleep Duration in Childhood Obesity
Annelies Eyck, Stijn Verhulst

29. Pediatric Metabolic Syndrome: Long-Term Risks for Type 2 Diabetes and Cardiovascular Disease
Costan G. Magnussen, Brooklyn J. Fraser, Olli T. Raitakari

30. Childhood Obesity, Atherogenesis, and Adult Cardiovascular Disease
Amy S. Shah, Elaine M. Urbina

31. Childhood Obesity and Cognitive Function
Dawn M. Eichen, Sara Appleton-Knapp, Kerri N. Boutelle

Part VIII. Treatment of Childhood Obesity: Lifestyle Intervention

32. Family-Based Behavioral Interventions for Childhood Obesity
Denise E. Wilfley, Katherine N. Balantekin

33. Exercise and Childhood Obesity
David Thivel, Grace O’Malley, Julien Aucouturier

34. School- and Community-Based Interventions for Childhood Obesity
Joel Gittelsohn, Sohyun Park

Part IX. Pharmacotherapy and Bariatric Surgery for Obesity and Co-morbidities

35. Role of Pharmacotherapy in theTreatment of Pediatric Obesity and Its Comorbidities
Aaron S. Kelly, Claudia K. Fox

36. Pathogenesis and Management of Adiposity and Insulin Resistance in Polycystic Ovary Syndrome (PCOS)
Thomas M. Barber, Jalini Joharatnam, Stephen Franks

37. Prevention and Treatment of Obesity and Metabolic Dysfunction in Children with Major Behavioral Disorders: Second-Generation Antipsychotics
Gloria Reeves, Linmarie Sikich

38. Bariatric Surgery in Adolescents
Daniel Relles, Jeffrey L. Zitsman

Part X. Challenges to Long-Term Success

39. The Role of the Primary Care Provider in Long-Term Counseling: Establishing a Therapeutic Alliance with the Child and Family
Sarah Armstrong, Joseph A. Jackson, Jessica Lyden Hoffman

40. The Sociocultural Context for Obesity Prevention and Treatment in Children and Adolescents: Influences of Ethnicity and Gender
Shiriki Kumanyika

Part XI. The Future of Childhood Obesity in the Global Marketplace

41. Fast-Food Value Chains and Childhood Obesity: A Global Perspective
Michelle Christian, Gary Gereffi

42. Why We Need Local, State, and National Policy-Based Approaches to Improve Children’s Nutrition in theUnited States
Megan Lott, Marlene Schwartz, Mary Story, Kelly D. Brownell

Nyckelord: Medicine & Public Health, Endocrinology, Pediatrics