Sigma Proteins: Evolution of the Concept of Sigma Receptors

1. Introduction to Sigma Proteins: Evolution of the Concept of Sigma Receptors
Felix J. Kim

2. Structural Insights into Sigma1 Function
Andrew Kruse

3. 3D Homology Model of Sigma1 Receptor
Erik Laurini, Domenico Marson, Maurizio Fermeglia, Sabrina Pricl

4. Medicinal Chemistry of σ1 Receptor Ligands: Pharmacophore Models, Synthesis, Structure Affinity Relationships, and Pharmacological Applications
Frauke Weber, Bernhard Wünsch

5. Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases
Tangui Maurice, Nino Goguadze

6. Sigma-1 Receptor and Neuronal Excitability
Saïd Kourrich

7. Sigma-1 Receptor and Pain
Manuel Merlos, Luz Romero, Daniel Zamanillo, Carlos Plata-Salamán, José Miguel Vela

8. Allosteric Modulation of Opioid G-Protein Coupled Receptors by Sigma1 Receptors
Gavril W. Pasternak

9. A Role for Sigma Receptors in Stimulant Self-Administration and Addiction
Jonathan L. Katz, Takato Hiranita, Weimin C. Hong, Martin O. Job, Christopher R. McCurdy

10. Sigma Receptors and Alcohol Use Disorders
Valentina Sabino, Pietro Cottone

11. Sigma1 Pharmacology in the Context of Cancer
Felix J. Kim, Christina M. Maher

12. Molecular Probes for Imaging the Sigma-2 Receptor: In Vitro and In Vivo Imaging Studies
Chenbo Zeng, Elizabeth S. McDonald, Robert H. Mach

Nyckelord: Biomedicine, Neurosciences, Human Physiology, Human Genetics, Cancer Research, Pharmaceutical Sciences/Technology