Precision Molecular Pathology of Prostate Cancer

Part I. General Principles

1. Precision Medicine in Prostate Cancer: Approach to the Patient
Beerinder S. Karir, Bishoy M. Faltas, Scott T. Tagawa

2. Epidemiology and Etiology
Padraic O’Malley

3. High-Grade Prostatic Intraepithelial Neoplasia
Fadi Brimo

4. Pathology of Prostate Cancer
Shaham Beg, Francesca Khani, Brian D. Robinson

5. Genetic Susceptibility
John P. Greene, Stephen P. Finn

6. Racial Differences
Francesca Khani, Brian D. Robinson

7. Cancer Stem Cells
Yanjing Li, Jiaoti Huang

Part II. Molecular Signatures of Primary Prostate Cancer

8. Prostate Cancer Risk: Single Nucleotide Polymorphisms (SNPs)
Robert J. Klein

9. Copy Number Variation/Chromosomal Aberration
Olivier Elemento

10. Gene Fusions
Andrea Sboner

11. Gene Expression Analysis
Michael Ittmann

12. Next-Generation Sequencing
Anne Offermann, Sven Perner

13. Epigenetic Alterations in Primary Prostate Cancer
Fátima Valdés-Mora, Clare Stirzaker

14. Proteomics in Prostate Cancer Research
Samantha E. T. Larkin, Benjamin Abbott, Michael D. Brown, Thomas R. Jackson, Noel W. Clarke, Paul A. Townsend

15. Metabolomic-Based Stratification in Prostate Cancer
Stefano Cacciatore, Giorgia Zadra, Massimo Loda

16. Tumor Microenvironment: Prospects for Diagnosis and Prognosis of Prostate Cancer Based on Changes in Tumor-Adjacent Stroma
Zhenyu Jia, Chung Lee, Xiaolin Zi, Michael McClelland, Dan Mercola

Part III. Molecular Signatures of Advanced Prostate Cancer

17. Metastatic Prostate Cancer
Verena Sailer

18. Castration-Resistant Prostate Cancer
Alastair H. Davies, Jennifer L. Bishop, Amina Zoubeidi

19. Neuroendocrine Prostate Cancer
Shaham Beg, Juan Miguel Mosquera

Part IV. Key Molecular Pathways in Prostate Cancer Development and Progression

20. The Role of Androgen Receptor in Prostate Cancer
Adeline Berger, David S. Rickman

21. PI3K/Akt/mTOR/PTEN and ERK/MAPK Pathways
Tamara L. Lotan

22. The Cell Cycle and Androgen Signaling Interactions in Prostate Cancer
Simone Brot, Nigel P. Mongan

23. DNA Damage Repair
Jacqueline Fontugne

24. Tyrosine Kinase Receptor Signaling in Prostate Cancer
Heather Johnson, Lingwu Chen, Kefeng Xiao, Jenny L. Persson

25. Microtubules in Prostate Cancer
Paraskevi (Evi) Giannakakou, Giuseppe Galletti

Part V. Precision Medicine Approach: Diagnosis, Treatment, Prognosis

26. Prostate Cancer Tissue Diagnosis
Joshua I. Warrick, Scott A. Tomlins

27. Molecular Imaging of Prostate Cancer: Radiopharmaceuticals for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT)
Shankar Vallabhajosula, Berna D. Polack, John W. Babich

28. Prostate Cancer Molecular Prognosis
Joshua I. Warrick, Scott A. Tomlins

29. Molecular Targeted Therapies of Prostate Cancer
Panagiotis J. Vlachostergios, Marcia Paddock, Ana M. Molina

30. Overview of Prostate Cancer Molecular Classification
Juan-Miguel Mosquera, Brian D. Robinson, Peyman Tavassoli

Nyckelord: Medicine & Public Health, Pathology, Oncology, Urology