Dermal Drug Selection and Development

1. Introduction
Lionel Trottet, Howard Maibach

2. Choosing Topical Drug Candidate: Historical Overview
Lionel Trottet, Howard Maibach

3. Key Factors Affecting the Efficacy of a Topical Drug Candidate: Learnings from Past Topical Drug Development
Lionel Trottet, Howard Maibach

4. Topical Versus Oral/Systemic Drug Discovery
Lionel Trottet, Howard Maibach

5. Assessing Drug Concentration in Skin: Direct and Indirect Methods
Lionel Trottet, Howard Maibach

6. Assessing Topical Efficacy
Lionel Trottet, Howard Maibach

7. Assessing Therapeutic Index
Lionel Trottet, Howard Maibach

8. Topical Vehicle Selection: Myths and Reality
Lionel Trottet, Howard Maibach

9. Dermal Drug Development Strategies
Lionel Trottet, Howard Maibach

10. Topical Drug Candidate Selection Criteria and Cascade
Lionel Trottet, Howard Maibach

11. Selecting Dermal Drug Candidate: Some Useful Quotations and “Rules”
Lionel Trottet, Howard Maibach

12. Conclusions and Perspectives
Lionel Trottet, Howard Maibach

Nyckelord: Biomedicine, Pharmaceutical Sciences/Technology, Dermatology