Neurodegenerative Diseases

Part I. Major Neurodegenerative Conditions

1. Alzheimer’s Disease: Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Neurons
Anne E. Harasta, Lars M. Ittner

2. Clinical Aspects of Alzheimer’s Disease
Fiona Kumfor, Glenda M. Halliday, Olivier Piguet

3. Parkinson’s Disease: Basic Pathomechanisms and a Clinical Overview
Alastair Noyce, Rina Bandopadhyay

4. Huntington’s Disease: Pathogenic Mechanisms and Therapeutic Targets
Dean J. Wright, Thibault Renoir, Laura J. Gray, Anthony J. Hannan

5. The Complexity of Clinical Huntington’s Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers
Lynette J. Tippett, Henry J. Waldvogel, Russell G. Snell, Jean-Paul Vonsattel, Anne B. Young, Richard L. M. Faull

6. Motoneuron Disease: Basic Science
Hristelina Ilieva, Nicholas J. Maragakis

7. Motoneuron Disease: Clinical
Hristelina Ilieva, Nicholas J. Maragakis

8. Multiple Sclerosis: Basic and Clinical
Katherine Buzzard, Wing Hei Chan, Trevor Kilpatrick, Simon Murray

Part II. Other Neurological Conditions

9. Schizophrenia: Basic and Clinical
Joseph T. Coyle

10. Stroke: Basic and Clinical
Tarvinder P. Singh, Jonathan R. Weinstein, Sean P. Murphy

11. Epileptic Encephalopathies as Neurodegenerative Disorders
Ingo Helbig, Markus Deimling, Eric D. Marsh

12. Neurodegeneration and Pathology in Epilepsy: Clinical and Basic Perspectives
Jordan S. Farrell, Marshal D. Wolff, G. Campbell Teskey

13. Prion Diseases
Benjamin C. Whitechurch, Jeremy M. Welton, Steven J. Collins, Victoria A. Lawson

14. Leukodystrophy: Basic and Clinical
Gerald V. Raymond

15. Traumatic Brain Injury as a Trigger of Neurodegeneration
Victoria E. Johnson, William Stewart, John D. Arena, Douglas H. Smith

Part III. Key Background and Key Technologies

16. Cell Death Mechanisms of Neurodegeneration
Jing Fan, Ted M. Dawson, Valina L. Dawson

17. Neuroglia: Functional Paralysis and Reactivity in Alzheimer’s Disease and Other Neurodegenerative Pathologies
Alexei Verkhratsky, Robert Zorec, J. J. Rodriguez, Vladimir Parpura

18. Advances in Neuroimaging for Neurodegenerative Disease
Michele Veldsman, Natalia Egorova

19. Gene Linkage and Systems Biology
Mark R. Cookson

20. Biomarkers in Neurodegenerative Diseases
Andreas Jeromin, Robert Bowser

Nyckelord: Biomedicine, Neurosciences