Chemical Mixtures and Combined Chemical and Nonchemical Stressors

1. Introduction
Cynthia V. Rider, Jane Ellen Simmons

Part I. Combined Exposures

2. Biomonitoring to Assess Exposures to Mixtures of Environmental Chemicals
Antonia M. Calafat

3. Considerations for Measuring Exposure to Chemical Mixtures
L. Blair Paulik, Kim A. Anderson

4. Modeling Complex Exposures
Dimosthenis A. Sarigiannis, Spyros P. Karakitsios

Part II. Prioritizing Mixtures for Study

5. Introduction to Environment and Exposome-Wide Association Studies: A Data-Driven Method to Identify Multiple Environmental Factors Associated with Phenotypes in Human Populations
Chirag J. Patel

6. Ecological Assembly of Chemical Mixtures
Rogelio Tornero-Velez, Peter P. Egeghy

7. Adverse Outcome Pathways to Support the Assessment of Chemical Mixtures
Mark D. Nelms, Jane Ellen Simmons, Stephen W. Edwards

Part III. Toxicology

8. Dose-Response Modeling
Gregg E. Dinse, David M. Umbach

9. Predicting Mixture Toxicity with Models of Additivity
Cynthia V. Rider, Gregg E. Dinse, David M. Umbach, Jane Ellen Simmons, Richard C. Hertzberg

10. Mixtures: Contrasting Perspectives from Toxicology and Epidemiology
Thomas F. Webster

11. Comparing Predicted Additivity Models to Observed Mixture Data
Chris Gennings

12. Physiologically Based Pharmacokinetic Modeling of Chemical Mixtures
Sami Haddad

13. Mixture Experimental Design
Jane Ellen Simmons, Ingvar Eide, Glenn Rice, Paul Feder

Part IV. Chemical Mixtures Risk Assessment

14. Component-Based Risk Assessment Approaches with Additivity and Interactions
Richard C. Hertzberg, M. Moiz Mumtaz

15. Assessing Human Health Risks Using Information on Whole Mixtures
Glenn E. Rice, Ingvar Eide, Paul I. Feder, Chris Gennings

Part V. Nonchemical Stressors

16. Consideration of Physical Stressors in Cumulative Risk Assessment
Cynthia V. Rider, Thais Morata, MaryJane K. Selgrade, Kenneth Sexton

17. Psychosocial and Chemical Stressors
Jane E. Clougherty, Jonathan I. Levy

18. Community-Based Cumulative Impact Assessment: California’s Approach to Integrating Nonchemical Stressors into Environmental Assessment Practices
Shannon R. Murphy, Shankar B. Prasad, John B. Faust, George V. Alexeeff

Nyckelord: Biomedicine, Pharmacology/Toxicology, Epidemiology, Environmental Health