Bone Toxicology

Part I. Bone Toxicology in Preclinical Drug Testing

1. Introduction and Considerations in Bone Toxicology
Susan Y. Smith, Nancy Doyle, Melanie Felx

2. Bone Physiology and Biology
Jürg Andreas Gasser, Michaela Kneissel

3. Specific Considerations for Bone Evaluations for Pediatric Therapeutics
Keith Robinson

4. Animal Models in Bone Research
Donald B. Kimmel

Part II. Methods in Bone Research

5. Biochemical Markers of Bone Turnover
Susan Y. Smith, Rana Samadfam

6. Skeletal Imaging
Aurore Varela

7. Biomechanics
Angela S. P. Lin, Gabrielle Boyd, Aurore Varela, Robert E. Guldberg

8. Application of Histopathology and Bone Histomorphometry for Understanding Test Article-Related Bone Changes and Assessing Potential Bone Liabilities
Reinhold G. Erben, Jacquelin Jolette, Luc Chouinard, Rogely Boyce

Part III. Bone as an Endocrine Organ

9. Bone and Muscle
Chenglin Mo, Zhiying Wang, Lynda Bonewald, Marco Brotto

10. Pituitary Hormone-Driven Mechanism for Skeletal Loss
Tony Yuen, Li Sun, Wahid Abu-Amer, Peng Liu, Terry F. Davies, Harry C. Blair, Maria New, Alberta Zallone, Mone Zaidi

11. Kidney–Bone: Interaction
Olena V. Andrukhova, Reinhold G. Erben

12. Bone and the Immune System
M. Neale Weitzmann

13. Bone and the Central Nervous System
Rishikesh N. Kulkarni, Paul A. Baldock

14. Intestinal Microbiota and Bone Health: The Role of Prebiotics, Probiotics, and Diet
Fraser L. Collins, Soon Mi Kim, Laura R. McCabe, Connie M. Weaver

15. Bone and Energy Metabolism
Clifford J. Rosen

Nyckelord: Biomedicine, Pharmacology/Toxicology, Pharmaceutical Sciences/Technology, Animal Models