Imaging and Focal Therapy of Early Prostate Cancer

Part I. Why Focal Therapy?

1. Evolution in the Concept of Focal Therapy: The Story of Breast Cancer and Prostate Cancer
Isabel García-Fleury, Chi-hang Yee, Marco Antonio López-Tovar, Adriana Pesci-Feltri, Arjun Sivaraman, Rafael Sanchez-Salas

2. Targeted Therapy for Localized Kidney Cancer
Zhamshid Okhunov, Roshan M. Patel, Jaime Landman

3. Focal Therapy for Prostate Cancer: A Guide for Patients
Kae Jack Tay, Thomas J. Polascik

Part II. Global Perspective of Active Surveillance and Focal Therapy

4. Low-Risk Prostate Cancer in North America: Rationale, Uptake, and Limitations of Active Surveillance and Opportunities for Focal Therapy
Raj Satkunasivam, Laurence Klotz

5. Focal Therapy and Active Surveillance in Europe
Jan Philipp Radtke, Angelo Territo, Markus Hohenfellner, Alberto Breda

6. Focal Therapy and Active Surveillance of Prostate Cancer in East and Southeast Asia
Masaki Kimura, Kae Jack Tay, Satoru Muto, Shigeo Horie

Part III. Scientific Foundation for the Focal Therapy Concept

7. Pathologic Rationale for Focal Therapy of Prostate Cancer: Elucidating Tumor Characteristics and Biology
Vladimir Mouraviev, Arnauld Villers, Thomas M. Wheeler, Rodolfo Montironi, Pierre Nevoux, Ariel Schulman, Thomas J. Polascik

8. Identifying and Characterizing the Index Lesion
Lina Maria Carmona Echeverria, Hayley Whitaker, Hashim U. Ahmed

9. Utilizing Biopsy-Based Genomic Assays to Risk-Stratify Patients
Robert Qi, Stephen J. Freedland, Judd W. Moul

10. Patient Selection for Focal Therapy of Prostate Cancer
Arjun Sivaraman, Rafael Sanchez-Salas

11. Prostate Focal Therapy: Definitions and Common Terminology
John F. Ward

Part IV. Multiparametric MRI and ARFI Imaging of the Prostate

12. Reading and Reporting Standards: The Prostate Imaging Reporting and Data System—What Is It and What Can It Do?
Wulphert Venderink, Jurgen J. Fütterer

13. Role of Magnetic Resonance Imaging in Prostate Cancer Assessment
Sonia Gaur, Sherif Mehralivand, Baris Turkbey, Peter L. Choyke

14. Optimizing Multiparametric Magnetic Resonance Imaging for a Focal Therapy Practice: Quality Improvement
Jamie N. Holtz, Rajan T. Gupta

15. Acoustic Radiation Force Impulse Imaging for Targeting: Correlation with Histology
Mark L. Palmeri, Kathryn R. Nightingale

Part V. Prostate Biopsy Techniques

16. In-Bore Magnetic Resonance Imaging-Targeted Prostate Biopsy
Igor Trilisky, Aytekin Oto, Scott Eggener

17. Multiparametric MRI/TRUS Fusion Biopsy, Outcomes, and Commercial Systems
Akhil Muthigi, Ardeshir R. Rastinehad, Arvin K. George, Masakatsu Oishi, Osamu Ukimura, Peter A. Pinto

18. Detecting, Localizing, and Treating the Multiparametric Magnetic Resonance Imaging Invisible Lesion: Utilizing Three-Dimensional Transperineal Mapping
Nelson N. Stone, E. David Crawford

19. Multiparametric Transrectal Ultrasound Biopsy
Arnoud W. Postema, Jochen Walz, Hessel Wijkstra

20. Robotic Magnetic Resonance Imaging Targeting for Biopsy and Therapy
Wesley W. Ludwig, Mohamad E. Allaf, Dan Stoianovici

Part VI. Technologies for Focal Therapy: Transperineal Approach

21. In-Bore Transperineal Magnetic Resonance Imaging-Guided Laser Ablation
Nathan Perlis, John Trachtenberg, Sangeet Ghai

22. Focal Cryotherapy
Kae Jack Tay, Efrat Tsivian, Thomas J. Polascik

23. Photodynamic Therapy for Early Prostate Cancer
Caroline M. Moore, Mark Emberton

Part VII. Technologies for Focal Therapy: Transrectal Approach

24. High-Intensity Focused Ultrasound
Paolo Capogrosso, Eric Barret

25. Transrectal Laser Focal Therapy of Prostate Cancer
John F. Feller, Bernadette M. Greenwood, R. Jason Stafford

Part VIII. New Approaches and Applications of Focal Therapy

26. Focal Therapy for Prostate Cancer: A Molecular Biology Approach with TRAIL
Vikram Narayan, Badrinath R. Konety, Thomas S. Griffith

27. Focal Brachytherapy and Intensity-Modulated Radiation Therapy
R. Alex Hsi

28. Focal Therapy for Anterior Cancers (Originated from Transition Zone)
Arnauld Villers, Kae Jack Tay

Part IX. Manipulating the Microenvironment for Optimization

29. The Story of Adjuvants to Boost the Performance of Cryoablation
Kimberly L. Santucci, John M. Baust, Kristi K. Snyder, Anthony Robilotto, Robert G. VanBuskirk, John G. Baust

30. 5-Alpha-Reductase Inhibition as a Secondary Preventive Strategy
Nathan Perlis, Antonio Finelli

Part X. Determining Outcomes of Focal Therapy

31. Measuring Patient-Based Outcomes: Setting Realistic Expectations When Balancing Functional Outcomes with Cancer Control
Behfar Ehdaie, Arjun Sivaraman

32. Pathologic Assessment and Implications Following Focal Therapy of Prostate Cancer
Rafael E. Jimenez, Andrew Evans, James Kench, Rodolfo Montironi, Mahul B. Amin

33. Posttreatment Surveillance Using Multiparametric Magnetic Resonance Imaging
Alex Kirkham

34. Determining Focal Therapy Failure and Salvage Options
Theo M. Reijke, Arnoud W. Postema, J. Stephen Jones

35. Positioning Focal Therapy from Consensus to Guidelines
Matthijs J. V. Scheltema, Anouk E. Hentschel, Jean J. M. C. H. Rosette

Nyckelord: Medicine & Public Health, Urology, Oncology, Imaging / Radiology