Total Intravenous Anesthesia and Target Controlled Infusions

Part I. Introduction/Background

1. When and How Did It All Begin? A Brief History of Intravenous Anesthesia
John William Sear

2. The Development and Regulation of Commercial Devices for Target-Controlled Drug Infusion
John B. Glen

3. The Memory Labyrinth: Systems, Processes, and Boundaries
Robert A. Veselis

4. Consciousness and Anesthesia
Ram Adapa

5. Mechanisms of Intravenous Anesthetic Action
Hugh C. Hemmings, Karl F. Herold

Part II. Principles of Pharmacological Modeling

6. Basic Pharmacology: Kinetics and Dynamics for Dummies
Johan Ræder

7. Pharmacokinetic–Pharmacodynamic Modelling of Anesthetic Drugs
Johannes Hans Proost

8. Principles of Target-Controlled Infusions
Steven L. Shafer

9. Performance of Target-Controlled Infusion Systems
Matthew T. V. Chan

10. How to Select a PK/PD Model
Kenichi Masui

Part III. Pharmacology of the Intravenous Anesthetic Agents

11. Propofol PK-PD
Douglas J. Eleveld

12. Etomidate and Etomidate Analogues: Molecular Pharmacology and Behavioral Actions
Douglas E. Raines

13. Dexmedetomidine: The Science and Clinical Aspects in Adults and Children
Mohamed Mahmoud

14. Clinical Effects and Applications of Ketamine
Mark G. Roback

15. Neuromuscular Blocking Drugs: Physiology, Pharmacology and Clinical Aspects
Claude Meistelman

16. New and Upcoming Drugs: Intravenous Anesthetic Agents
John William Sear

17. Drug Interactions in Anesthesia
Jaap Vuyk

Part IV. Practical Conduct of Sedation and Anesthesia

18. Pump Pitfalls and Practicalities
Frank Engbers

19. EEG Monitoring of Depth of Anesthesia
Michael R. J. Sury

20. Monitoring the Analgesic Component of Anesthesia
Isabelle Constant

21. Intravenous Drugs for Sedation: Target-Controlled, Patient-Controlled and Patient-Maintained Delivery
Keith J. Anderson, Gavin N. C. Kenny

22. Pediatric TIVA/TCI: Case Presentations and Discussion
Vivian Man-ying Yuen

23. TCI/TIVA Adult Case Studies
Nicholas Sutcliffe

Part V. Special Populations and Procedures

24. Intravenous Anesthesia in Obese Patients
Pablo O. Sepúlveda V., Luis Ignacio Cortínez

25. Pharmacokinetics and Pharmacodynamics in the Pediatric Patient
Brian J. Anderson

26. Clinical Pharmacology of Intravenous Sedation in Children
Oliver Bagshaw

27. Sedation of the Critically Ill Child
Arno Brouwers, Sanne Vaassen, Gijs D. Vos, Jan N. M. Schieveld, Piet L. Leroy

28. TCI and TIVA for Neurosurgery: Considerations and Techniques
Massimo Lamperti, Fazil Ashiq

29. TCI in Special Patients Groups: The Elderly and Obese
Frederique S. Servin

30. TIVA for Cardiac Surgery
Stefan Schraag

31. TIVA/TCI in Veterinary Practice
Thierry Beths

Part VI. Outcome, Education, Safety, and the Future

32. Advantages, Disadvantages, and Risks of TIVA/TCI
Ken B. Johnson

33. Economics of TIVA
Jane Montgomery, Mary Stocker

34. Teaching TCI with Human Patient Simulators
Wolfgang Heinrichs

35. Closed-Loop or Automated Titration of Intravenous Anesthesia: Background, Science, and Clinical Impact
Ngai Liu

36. Health Care Technology, the Human–Machine Interface, and Patient Safety During Intravenous Anesthesia
Craig S. Webster

37. Can IV Sedatives Affect Outcome?
Christopher G. Hughes, Christina J. Hayhurst, Pratik P. Pandharipande

38. The Benefit and Future of Pharmacogenetics
Janko Samardzic, Dubravka Svob Strac, John N. Anker

39. Lessons From Drug Interaction Displays
Ross Kennedy

40. The Role of Intravenous Agents in Delirium
Claudia Spies, Susanne Koch, Alissa Wolf, Rudolf Mörgeli, Björn Weiss

41. Perioperative Cardioprotective Strategies in Noncardiac Surgery
Stefan Hert

42. Opioid-Induced Hyperalgesia After Surgery: Clinical Relevance
Philippe Richebe, Cyrip Rivat

43. Memory, Awareness and Intravenous Anesthetics
Michael Wang

44. Awareness and Dreaming During TIVA
Kate Leslie

45. Apoptosis and Neurocognitive Effects of IV Anesthetics
Sulpicio G. Soriano, Laszlo Vutskits

Nyckelord: Medicine & Public Health, Anesthesiology, Traumatic Surgery