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Baxter, Cheryl

The CAPRISA Clinical Trials: HIV Treatment and Prevention

Baxter, Cheryl - The CAPRISA Clinical Trials: HIV Treatment and Prevention, e-bok


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ISBN: 9783319475189

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Table of contents

Part I. Introduction/Background

1. Studies Linked to the Evolving HIV Epidemic in South Africa: Informing the CAPRISA Scientific Agenda
Quarraisha Abdool Karim, Cheryl Baxter, Salim S. Abdool Karim

2. CAPRISA: Establishing a Research Centre to Undertake HIV Clinical Trials
Salim S. Abdool Karim, Cheryl Baxter, Quarraisha Abdool Karim

3. Overview of Clinical Trials
Anneke Grobler

Part II. CAPRISA Clinical Trials for HIV and HSV-2 Prevention

4. Antiretrovirals for HIV Prevention: The CAPRISA 004 Tenofovir Gel Trial
Cheryl Baxter, Leila E. Mansoor, Tanuja N. Gengiah, Salim S. Abdool Karim, Quarraisha Abdool Karim

5. Rolling Out of Tenofovir Gel in Family Planning Clinics: The CAPRISA 008 Implementation Trial
Leila E. Mansoor, Kathryn T. Mngadi, Quarraisha Abdool Karim

6. The Impact of Conditional Cash Transfers in Reducing HIV in Adolescent Girls and Boys (RHIVA): The CAPRISA 007 Matched Pair, Cluster Randomised Controlled Trial
Hilton Humphries, Ayesha B. M. Kharsany, Kerry Leask, Fanelesibonge Ntombela, Quarraisha Abdool Karim

7. HIV Vaccine and Passive Immunity Trials
Nigel Garrett, Kathryn Mngadi, Nivashnee Naicker, Lynn Morris

Part III. CAPRISA Clinical Trials for HIV–TB Treatment

8. CAPRISA 003: Timing of Antiretroviral Initiation in HIV-TB Co-infected Patients—The SAPiT Trial
Nesri Padayatchi, Kogie Naidoo, Andy Gray, Salim S. Abdool Karim, Anneke Grobler

9. Scaling up TB-HIV Integration in Public Health Clinics: Translating Research Findings into Practice
Kogieleum Naidoo, Santhanalakshmi Gengiah, Nesri Padayatchi, Salim S. Abdool Karim

Part IV. Experiences and Lessons Learnt from Clinical Trials in CAPRISA

10. From Bench to Bedside: Lessons from HIVNatural History Cohort Studies
Carolyn Williamson, Lynn Morris, Nigel Garrett, Penny Moore, Wendy Burgers, Koleka Mlisana

11. Advancing Understanding of HIV Infection in Women Through Mucosal Immunology Studies
Jo-Ann S. Passmore, Lenine L. Liebenberg, Nonhlanhla N. Mkhize, Derseree Archary, Lindi Masson

Part V. Essential Support Activities for the Conduct of Clinical Trials

12. Good Practices in the Conduct of Clinical Trials: Good Community, Pharmacy and Laboratory Practices
Tanuja N. Gengiah, Natasha Samsunder, Janet A. Frohlich, Fanelesibonge Ntombela

13. Ethical and Legal Considerations for Realising Post-trial Access of Novel Experimental Interventions: Lessons from the CAPRISA 004 Trial
Jerome Amir Singh

14. Grants Management
Marian Swart, Devenie Latchmanan, Nasrin Amla, Carl Montague

15. Taking Science to the People: CAPRISA Communication and Media Strategies for Announcing Outcomes of Pivotal Study Findings
Smita Maharaj

16. What Does the Future Hold for CAPRISA?
Salim S. Abdool Karim, Cheryl Baxter, Quarraisha Abdool Karim

Nyckelord: Medicine & Public Health, Health Promotion and Disease Prevention, Infectious Diseases, Health Informatics

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