Nitrite and Nitrate in Human Health and Disease

Part I. Biochemistry, Molecular Biology, Metabolism and Physiology

1. Introduction
Nathan S. Bryan, Joseph Loscalzo

2. From Atmospheric Nitrogen to Bioactive Nitrogen Oxides
Mark Gilchrist, Nigel Benjamin

3. Nitrate-Reducing Oral Bacteria: Linking Oral and Systemic Health
Nathan S. Bryan, Joseph F. Petrosino

4. Epigenetics and the Regulation of Nitric Oxide
Diane E. Handy, Joseph Loscalzo

5. The Mitochondrion: A Physiological Target of Nitrite
Danielle A. Guimaraes, Chris Reyes, Sruti Shiva

6. Sources of Exposure to Nitrogen Oxides
Andrew L. Milkowski

Part II. Food and Environmental Exposures to Nitrite and Nitrate

7. History of Nitrite and Nitrate in Food
Jimmy T. Keeton

8. Nutritional Epidemiology of Nitrogen Oxides: What Do the Numbers Mean?
Martin Lajous, Walter C. Willett

9. Nutritional Impact on the Nitric Oxide Pathway
Wing Tak Wong, John P. Cooke

10. Dietary Flavonoids as Modulators of NO Bioavailability in Acute and Chronic Cardiovascular Diseases
Matthias Totzeck, Tienush Rassaf

11. Nitrite and Nitrate in Human Breast Milk: Implications for Development
Pamela D. Berens, Nathan S. Bryan

12. Regulation of Dietary Nitrate and Nitrite: Balancing Essential Physiological Roles with Potential Health Risks
Norman G. Hord, Melissa N. Conley

Part III. Nitrite and Nitrate in Therapeutics and Disease

13. Nitric Oxide Signaling in Health and Disease
Nathan S. Bryan, Jack R. Lancaster

14. Inhaled Nitric Oxide
Kenneth D. Bloch, Andrea U. Steinbicker, Lisa Lohmeyer, Rajeev Malhotra

15. Pharmacology of Nitrovasodilators
Thomas Münzel, Andreas Daiber

16. Nitrite and Nitrate in Ischemia–Reperfusion Injury
David J. Lefer, Nathan S. Bryan, Chelsea L. Organ

17. Nitrite and Nitrate as a Treatment for Hypertension
Vikas Kapil

18. Nitrate and Nitrite in Aging and Age-Related Disease
Lawrence C. Johnson, Allison E. DeVan, Jamie N. Justice, Douglas R. Seals

19. The Nitrate–Nitrite–Nitric Oxide Pathway in Traditional Herbal Medicine and Dietary Supplements with Potential Benefits for Cardiovascular Diseases
Yong-Jian Geng

20. Nitrate and Exercise Performance
Stephen J. Bailey, Anni Vanhatalo, Andrew M. Jones

21. Nitrite and Nitrate in Cancer
David M. Klurfield

22. Looking Forward
Nathan S. Bryan, Joseph Loscalzo

Nyckelord: Medicine & Public Health, Clinical Nutrition, Medical Biochemistry, Ecotoxicology