Kimko, Holly H.C.
Systems Pharmacology and Pharmacodynamics
Part I. Systems Modeling
1. Systems Pharmacology and Pharmacodynamics: An Introduction
Donald E. Mager, Holly H. C. Kimko
2. Role of Systems Modeling in Regulatory Drug Approval
Vikram Sinha, Shiew-Mei Huang, Darrell R. Abernethy, Yaning Wang, Ping Zhao, Issam Zineh
3. Quantitative Systems Pharmacology: Applications and Adoption in Drug Development
Saroja Ramanujan, Kapil Gadkar, Ananth Kadambi
4. Systems Pharmacology: An Overview
Marc R. Birtwistle, Jens Hansen, James M. Gallo, Sreeharish Muppirisetty, Peter Man-Un Ung, Ravi Iyengar, Avner Schlessinger
5. Discrete Dynamic Modeling: A Network Approach for Systems Pharmacology
Steven Nathaniel Steinway, Rui-Sheng Wang, Reka Albert
6. Kinetic Models of Biochemical Signaling Networks
Mehdi Bouhaddou, Marc R. Birtwistle
7. Mechanistic Models of Physiological Control Systems
Michael C. K. Khoo, Wen-Hsin Hu, Patjanaporn Chalacheva
Part II. Pharmacodynamics
8. Foundations of Pharmacodynamic Systems Analysis
William J. Jusko
9. Direct, Indirect, and Signal Transduction Response Modeling
Wojciech Krzyzanski
10. Irreversible Pharmacodynamics
Alberto Russu, Italo Poggesi
11. Feedback Control Indirect Response Models
Yaping Zhang, David Z. D’Argenio
12. Nonlinear Mixed Effects Modeling in Systems Pharmacology
Peter L. Bonate, Amit Desai, Ahsan Rizwan, Zheng Lu, Stacey Tannenbaum
13. Detecting Pharmacokinetic and Pharmacodynamic Covariates from High-Dimensional Data
Jonathan Knights, Murali Ramanathan
Part III. Multi-scale Models of Drug Action
14. Multi-scale Modeling of Drug Action in the Nervous System
Hugo Geerts, Patrick Roberts, Athan Spiros, Robert Carr
15. Mechanistic Modeling of Inflammation
Jeremy D. Scheff, Kubra Kamisoglu, Ioannis P. Androulakis
16. Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities
Yoshiaki Kariya, Masashi Honma, Hiroshi Suzuki
17. Translational Modeling of Antibacterial Agents
Gauri G. Rao, Neang S. Ly, Brian T. Tsuji, Jürgen B. Bulitta, Alan Forrest
18. Viral Dynamic Modeling of Hepatitis C Virus Infection: Past Successes and Future Challenges
Eric L. Haseltine, Holly H. C. Kimko
19. Using Systems Pharmacology to Advance Oncology Drug Development
Daniel C. Kirouac
20. Systems Pharmacology Modeling in Type 2 Diabetes Mellitus
James R. Bosley, Tristan S. Maurer, Cynthia J. Musante
Nyckelord: Biomedicine, Pharmaceutical Sciences/Technology, Mathematical and Computational Biology, Medical Biochemistry
- Utgivare
- Kimko, Holly H.C.
- Mager, Donald E.
- Utgivare
- Springer
- Utgivningsår
- 2016
- Språk
- en
- Utgåva
- 1
- Serie
- AAPS Advances in the Pharmaceutical Sciences Series
- Sidantal
- 13 sidor
- Kategori
- Hälsa, skönhet, mode
- Format
- E-bok
- eISBN (PDF)
- 9783319445342
- Tryckt ISBN
- 978-3-319-44532-8