Adhesion G Protein-coupled Receptors

1. Introduction: History of the Adhesion GPCR Field
Jörg Hamann, Alexander G. Petrenko

Part I. Molecular and Pharmacological Properties of Adhesion GPCRs

2. Classification, Nomenclature, and Structural Aspects of Adhesion GPCRs
Arunkumar Krishnan, Saskia Nijmeijer, Chris Graaf, Helgi B. Schiöth

3. 7TM Domain Structure of Adhesion GPCRs
Saskia Nijmeijer, Steffen Wolf, Oliver P. Ernst, Chris Graaf

4. Understanding the Structural Basis of Adhesion GPCR Functions
Demet Araç, Norbert Sträter, Elena Seiradake

5. Control of Adhesion GPCR Function Through Proteolytic Processing
Matthias Nieberler, Robert J. Kittel, Alexander G. Petrenko, Hsi-Hsien Lin, Tobias Langenhan

6. Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs
Ines Liebscher, Torsten Schöneberg

7. Versatile Signaling Activity of Adhesion GPCRs
Ayush Kishore, Randy A. Hall

8. Adhesion GPCR-Related Protein Networks
Barbara Knapp, Uwe Wolfrum

9. The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans
Peter Kovacs, Torsten Schöneberg

Part II. Adhesion GPCRs as Pharmakotargets in Organ Function and Development

10. Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors
Nicole Scholz, Kelly R. Monk, Robert J. Kittel, Tobias Langenhan

11. Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration
David Strutt, Ralf Schnabel, Franziska Fiedler, Simone Prömel

12. Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination
Séverine M. Sigoillot, Kelly R. Monk, Xianhua Piao, Fekrije Selimi, Breanne L. Harty

13. Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs
James P. White

14. Adhesion GPCR Function in Pulmonary Development and Disease
Marie-Gabrielle Ludwig, Klaus Seuwen, James P. Bridges

15. Adhesion GPCRs as Modulators of Immune Cell Function
Jörg Hamann, Cheng-Chih Hsiao, Chang Sup Lee, Kodi S. Ravichandran, Hsi-Hsien Lin

16. Heart Development, Angiogenesis, and Blood-Brain Barrier Function Is Modulated by Adhesion GPCRs
Gentian Musa, Felix B. Engel, Colin Niaudet

17. Adhesion GPCRs in Tumorigenesis
Gabriela Aust, Dan Zhu, Erwin G. Meir, Lei Xu

18. Erratum to: 7TM Domain Structure of Adhesion GPCRs
Saskia Nijmeijer, Steffen Wolf, Oliver P. Ernst, Chris Graaf

Nyckelord: Biomedicine, Pharmacology/Toxicology, Human Physiology, Human Genetics, Cell Biology, Medical Biochemistry