The Functional Nucleus

Part I. Nuclear Periphery

1. Human Diseases Related to Nuclear Envelope Proteins
Howard J. Worman

Part II. Nuclear Bodies

2. The Nucleolus: Structure and Function
Marie-Line Dubois, François-Michel Boisvert

3. Pre-mRNA Splicing and Disease
Michael R. Ladomery, Sebastian Oltean

4. Acute Promyelocytic Leukaemia: Epigenetic Function of the PML-RARα Oncogene
Julia P. Hofmann, Paolo Salomoni

Part III. Chromosomes

5. Spatial Genome Organization and Disease
Karen J. Meaburn, Bharat Burman, Tom Misteli

6. Telomeres and Chromosome Stability
Tsz Wai Chu, Chantal Autexier

Part IV. Nuclear Domains and Development

7. Polycomb Bodies
Vincenzo Pirrotta

8. The Continuing Flight of Ikaros
Karen E. Brown

Part V. Nuclear Domains and Cell Stress

9. Senescence Associated Heterochromatic Foci: SAHF
Tamir Chandra

10. DNA Repair Foci Formation and Function at DNA Double-Strand Breaks
Michael J. Hendzel, Hilmar Strickfaden

11. Nuclear Domains and DNA Repair
Jordan Pinder, Alkmini Kalousi, Evi Soutoglou, Graham Dellaire

12. The Interplay Between Inflammatory Signaling and Nuclear Structure and Function
Sona Hubackova, Simona Moravcova, Zdenek Hodny

13. Manipulation of PML Nuclear Bodies and DNA Damage Responses by DNA Viruses
Lori Frappier

Part VI. Macromolecular Dynamics Within the Nucleus

14. Energy-Dependent Intranuclear Movements: Role of Nuclear Actin and Myosins
Guillaume Huet, Maria K. Vartiainen

15. Nucleosome Dynamics Studied by Förster Resonance Energy Transfer
Alexander Gansen, Jörg Langowski

Part VII. Chromatin Transactions and Epigenetics

16. Mapping and Visualizing Spatial Genome Organization
Christopher J. F. Cameron, James Fraser, Mathieu Blanchette, Josée Dostie

17. Developmental Roles of Histone H3 Variants and Their Chaperones
Sebastian Müller, Dan Filipescu, Geneviève Almouzni

18. Epigenetics in Development, Differentiation and Reprogramming
Nuphar Salts, Eran Meshorer

19. Genomic Imprinting
Sanaa Choufani, Rosanna Weksberg

Part VIII. Transcription and RNA Metabolism

20. Transcription Factories
Christopher Eskiw, Jenifer Mitchell

21. Dynamics and Transport of Nuclear RNA
Jonathan Sheinberger, Yaron Shav-Tal

Nyckelord: Life Sciences, Nucleic Acid Chemistry, Cell Biology, Cytogenetics