Hepatocellular Carcinoma

Part I. Causes, Biological and Molecular Bases of HCC

1. Epidemiology of Hepatocellular Carcinoma
Donna L. White, Fasiha Kanwal, Li Jiao, Hashem B. El-Serag

2. Environmental Carcinogens and Risk for Human Liver Cancer
John D. Groopman

3. Molecular Mechanisms of Hepatocellular Carcinoma
Hani Alotaibi, Nese Atabey, Kasım Diril, Esra Erdal, Mehmet Ozturk

4. Chemically-Induced Hepatocarcinogenesis
Yvonne P. Dragan

5. Molecular Profiling of Human Hepatocellular Carcinoma
Anuradha Budhu, Xin Wei Wang

6. Genomic Signatures of Risk Factors and Molecular Identification of HCC Subtypes
Jean-Charles Nault, Jessica Zucman-Rossi

7. MicroRNAs and Hepatocellular Carcinoma
Aldo Cavallini

8. Nontumor Prognostic Factors in Hepatocellular Carcinoma
Nicolas Goossens, Ismail Labgaa, Augusto Villanueva

9. Gut Microbiota and HCC
Sven H. Loosen, Christoph Roderburg, Tom Luedde

10. Hepatocellular Carcinoma as a Paradigm for a Systemic Evolutionary Approach to Cancer
Antonio Mazzocca, Giovanni Ferraro, Giovanni Misciagna, Brian I. Carr

11. HCC and Its Microenvironment
Brian I. Carr

12. Circulating Tumor Cells (Liquid Tumor Biopsy) in Hepatocellular Carcinoma: Biology, Methodologies, and Clinical Implications
Zhengfeng Yin

13. Role of the Immune System in Hepatocellular Carcinoma: Implications for Existing and Novel Therapies
Tobias Flecken, Robert Thimme

14. Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma
Evgeny V. Denisov, Tatiana S. Gerashchenko, Marina V. Zavyalova, Vasiliy N. Manskikh, Evgeny L. Choinzonov, Nadezhda V. Cherdyntseva, Vladimir M. Perelmuter

15. Systemic Inflammation: A New Prognostic Domain and Source of Therapeutic Targets in Hepatocellular Carcinoma
David J. Pinato, Rohini Sharma

16. Hepatocellular Carcinoma Associated with Hepatitis B Virus
Inbal Houri, Oren Shibolet

17. Hepatitis C and Hepatocellular Carcinoma
Ryota Masuzaki, Tatsuo Kanda, Haruhiko Yoshida, Naoya Kato, Masao Omata

18. Obesity, NASH, and HCC
Chadia L. Robertson, Devanand Sarkar, Arun J. Sanyal

19. Metabolic Disease and Hepatocellular Carcinoma
David H. Thiel, Salamah Mohammad Alwahsh, Giuliano Ramadori

Part II. Diagnosis

20. Aspects of Hepatocellular Tumor Pathology
Michael A. Nalesnik

21. Protein Biomarkers in the Management of Hepatocellular Carcinoma: Novel Combinatory Approaches
Philip Johnson, Sarah Berhane

22. Surveillance for Hepatocellular Carcinoma
Cristina Della Corte, Massimo Colombo

23. Use of Imaging Techniques to Screen Hepatocellular Carcinoma
Satoshi Goshima

24. Ultrasound of Hepatocellular Carcinoma: The Important Contribution of Contrast Enhancement
Tae Kyoung Kim, Hyun-Jung Jang, Stephanie R. Wilson

25. MRI for Detection and Evaluation of Hepatocellular Carcinoma
Anuj Patel, Neil Malhotra, Christopher G. Roth, Sandeep Deshmukh, Donald G. Mitchell

26. Computed Tomography of HCC
Francesco Agnello, Giuseppe Brancatelli

27. Clinical Features and Clinician’s Diagnostic Approach to Hepatocellular Carcinoma
Tamar Thurm, Oren Shibolet

28. Current HCC Staging Systems: Their Uses and Limitations
Yukio Tokumitsu, Hiroaki Nagano

Part III. Therapies

29. Percutaneous Ethanol Injection
Tito Livraghi, Maria Franca Meloni, Anita Andreano

30. Thermal Ablative Treatments for Hepatocellular Carcinoma
Antonio Facciorusso, Michele Barone

31. Resection of Hepatocellular Carcinoma
Nir Lubezky, Yaacov Goykhman, Richard Nakache, Ido Nachmany

32. Liver Transplantation for Hepatocellular Carcinoma
Georg Györi, Pierre-Alain Clavien, Mickaël Lesurtel

33. Medical Therapy of HCC
Brian I. Carr, Srikanth Nagalla, Ravit Geva

34. Targeted Therapies for Hepatocellular Carcinoma
Susan Kralian, Brian I. Carr

35. Radiation Therapy for Hepatocellular Carcinoma
Andrew S. Kennedy

36. Psychosocial Issues in Hepatocellular Carcinoma
Jennifer L. Steel, Feridey N. Carr, Alexandra Savkova, Naadia Ahmed, Andrea DiMartini, Mary A. Dew

37. Bringing It All Together
Brian I. Carr

Nyckelord: Medicine & Public Health, Oncology, Hepatology, Surgical Oncology, Gastroenterology