Group Sequential and Confirmatory Adaptive Designs in Clinical Trials

Part I. Group Sequential Designs

1. Repeated Significance Tests
Gernot Wassmer, Werner Brannath

2. Procedures with Equally Sized Stages
Gernot Wassmer, Werner Brannath

3. Procedures with Unequally Sized Stages
Gernot Wassmer, Werner Brannath

4. Confidence Intervals, p-Values, and Point Estimation
Gernot Wassmer, Werner Brannath

5. Applications
Gernot Wassmer, Werner Brannath

Part II. Confirmatory Adaptive Designs with a Single Hypothesis

6. Adaptive Group Sequential Tests
Gernot Wassmer, Werner Brannath

7. Decision Tools for Adaptive Designs
Gernot Wassmer, Werner Brannath

8. Estimation and p-Values for Two-Stage Adaptive Designs
Gernot Wassmer, Werner Brannath

9. Adaptive Designs with Survival Data
Gernot Wassmer, Werner Brannath

Part III. Adaptive Designs with Multiple Hypotheses

10. Multiple Testing in Adaptive Designs
Gernot Wassmer, Werner Brannath

11. Applications and Case Studies
Gernot Wassmer, Werner Brannath

Nyckelord: Statistics, Statistics for Life Sciences, Medicine, Health Sciences, Biostatistics, Drug Safety and Pharmacovigilance, Pharmaceutical Sciences/Technology