Mitochondrial Dysfunction in Neurodegenerative Disorders

Part I. Mitochondria and Neurodegenerative Disease

1. An Introduction to Mitochondria, Their Structure and Functions
Eve Michelle Simcox, Amy Katherine Reeve

Part II. Mitochondrial Dysfunction: Causes and Effects?

2. Neurodegeneration in Mitochondrial Disorders
Jonathan Phillips, Hannah Hayhurst, Nichola Zoe Lax

3. The Ageing Brain, Mitochondria and Neurodegeneration
Gavin Hudson

4. Mitochondrial Genes and Neurodegenerative Disease
Carlo Viscomi, Anna Ardissone, Massimo Zeviani

5. Mitochondrial Signaling and Neurodegeneration
Martin Picard, Meagan J. McManus

Part III. Functional Consequences of Mitochondrial Dysfunction

6. Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson’s Disease
James Surmeier, Enrico Zampese, Daniel Galtieri, Paul T. Schumacker

7. Mitochondrial Dynamics and Neurodegeneration
Arnaud Mourier

8. Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation
Marija Sajic

9. Mitochondria, the Synapse, and Neurodegeneration
Alexia Chrysostomou, Doug M. Turnbull

10. Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration
Marthe H. R. Ludtmann, Andrey Y. Abramov

11. Mitochondrial Degradation, Autophagy and Neurodegenerative Disease
Elsje G. Otten, Diego Manni, Viktor I. Korolchuk

12. The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria
Matthew Nguyen, Ellen Sidransky, Wendy Westbroek

Part IV. Measuring the Contribution of Mitochondrial Dysfunction to Neurodegenerative Disease

13. Can We Accurately Model Mitochondrial Dysfunction in Neurodegeneration?
Marijana Aradjanski, Aleksandra Trifunovic

14. Mitochondrial Function and Dynamics Imaged In Vivo
Kim Chisholm, Fabian Peters, Dimitra G. Schiza, Mona Sadeghian, Kenneth Smith

Part V. The Future

15. Development of Treatments and Therapies to Target Mitochondrial Dysfunction
Stephen B. Helliwell

16. Summary and Conclusions
Amy Katherine Reeve

Nyckelord: Medicine & Public Health, Neurology, Medical Biochemistry, Neurosciences, Internal Medicine