Hayflick, Leonard
Cellular Ageing and Replicative Senescence
Part I. History and Origins
1. Origins of the Hayflick System, the Phenomenon and the Limit
Suresh I. S. Rattan
2. Experimental Foundations of the Hayflick System
Suresh I. S. Rattan
Part II. Serial Passaging and Progressive Changes
3. Slowing Down of the Cell Cycle During Fibroblast Proliferation
Alvaro Macieira-Coelho
4. Influence of Donor Age and Species Longevity on Replicative Cellular Senescence
Antonello Lorenzini, Andrea B. Maier
5. Ageing of the Stem Cells: The Conjoined Twosome Growing Old: Stem Cell and Its Niche
Günter Lepperdinger
6. Ageing and Senescence in Immune Cells In Vitro and In Vivo
Graham Pawelec, Yvonne Barnett
7. Telomeres Shortening: A Mere Replicometer?
Stella Victorelli, João F. Passos
8. Modeling Cellular Aging: An Introduction – Mathematical and Computational Approaches
Tarynn M. Witten
Part III. Ageing, Cancer and Senescence
9. Cell Cycle Checkpoints and Senescence
Renu Wadhwa, Zeenia Kaul, Sunil C. Kaul
10. Mitochondrial Reactive Oxygen Species in Cellular Senescence
Timothy Nacarelli, Claudio Torres, Christian Sell
11. Cellular Aging and Tumor Regulation
Andreas Simm, Barbara Seliger, Lars-Oliver Klotz
12. Biomarkers of Replicative Senescence Revisited
Jan O. Nehlin
Part IV. Ageing Modulators
13. Stress-Induced (Premature) Senescence
Florence Debacq-Chainiaux, Randa Ben Ameur, Emilie Bauwens, Elise Dumortier, Marie Toutfaire, Olivier Toussaint
14. Implications of Cellular Senescence on Aging and Disease in the Brain
Elizabeth P. Crowe, S. Ferit Tuzer, Justin Cohen, Emre C. Yetkin, Luca D’Agostino, Christian Sell, Claudio Torres
15. Small Noncoding RNAs in Senescence and Aging
Joseph M. Dhahbi
16. Targeting Senescent Cells to Improve Human Health
Tobias Wijshake, Jan M. A. Deursen
Part V. Recapitulation and Future Expectations
17. Unlike the Stochastic Events That Determine Ageing, Sex Determines Longevity
Leonard Hayflick
Nyckelord: Biomedicine, Cytogenetics, Cell Biology, Geriatrics/Gerontology
- Utgivare
- Hayflick, Leonard
- Rattan, Suresh I.S.
- Utgivare
- Springer
- Utgivningsår
- 2016
- Språk
- en
- Utgåva
- 1
- Serie
- Healthy Ageing and Longevity
- Sidantal
- 8 sidor
- Kategori
- Hälsa, skönhet, mode
- Format
- E-bok
- eISBN (PDF)
- 9783319262390
- Tryckt ISBN
- 978-3-319-26237-6