The Hsp60 Chaperonin

1. Introduction
Peter Bross

2. Historical Sketch of the Discovery and Recognition of the Function of Chaperonins
Peter Bross

3. Molecular Structure of Chaperonins
Peter Bross

4. Folding by Enclosure in the Chaperonin Cavity
Peter Bross

5. Evolutionary Origins and Family Relations
Peter Bross

6. Chaperoning Mechanisms: Folding Helpers, Folding Protectors, or Misfolding Blockers?
Peter Bross

7. Sequence Variations in Proteins Affecting Chaperonin Dependence
Peter Bross

8. Genetic Organization of Type I Chaperonin Genes
Peter Bross

9. Regulation of Type I Chaperonin Gene Expression
Peter Bross

10. Subcellular Localization
Peter Bross

11. Posttranslational Modifications
Peter Bross

12. Variations in Hsp60 and Hsp10 in Humans
Peter Bross

13. Type I Chaperonins Are Essential for Cell Viability
Peter Bross

14. Human Diseases Caused by Genetic Mutations in the Hsp60/Hsp10 System
Peter Bross

15. Molecular Investigations of Disease Mechanisms
Peter Bross

16. Outlook
Peter Bross

Nyckelord: Life Sciences, Protein Science, Bioorganic Chemistry, Molecular Medicine