Florez, Jose C.
The Genetics of Type 2 Diabetes and Related Traits
Part I. Genetic Discovery
1. Historical Overview of Gene Discovery Methodologies in Type 2 Diabetes
Amélie Bonnefond, Alan R. Shuldiner, Philippe Froguel
2. Genome-Wide Association Studies of Type 2 Diabetes
Rob Sladek, Inga Prokopenko
3. Genome-Wide Association Studies of Quantitative Glycaemic Traits
Inês Barroso, Robert Scott
4. Genome-Wide Association Studies (GWAS) of Adiposity
Erik Ingelsson, Tuomas O. Kilpeläinen
5. Sequencing Approaches to Type 2 Diabetes
Jeffrey W. Kleinberger, Toni I. Pollin
6. Fine-Mapping of Type 2 Diabetes Loci
Laura J. Scott, Karen L. Mohlke
7. Genetics of Diabetic Micro- and Macrovascular Complications
Niina Sandholm, Per-Henrik Groop, Alessandro Doria
Part II. Interpretation and Data Integration
8. Transferability Across Ethnic Groups
Richa Saxena, Nicholette D. Palmer
9. Physiology Insights
Richard M. Watanabe, Torben Hansen
10. Insights from Monogenic Diabetes
Tormund Salvesen Njølstad, Sian Ellard, Pål Rasmus Njølstad
11. Epigenetics in Type 2 Diabetes
Charlotte Ling, Lorenzo Pasquali
12. Gene-Environment Interaction: Methods and Examples in Type 2 Diabetes and Obesity
Alisa K. Manning
13. The Gut Microbiota in Type 2 Diabetes
Trine Nielsen, Kristine H. Allin, Oluf Pedersen
Part III. From Association to Function
14. Transcription Factor 7-Like 2 (TCF7L2)
Struan F. A. Grant, Leif Groop
15.
Marju Orho-Melander, Anna L. Gloyn
16. Genetic and Functional Studies Implicate
Nabila Bouatia-Naji, Richard M. O’Brien
17. From Association to Function:
Michael N. Weedon, Peter Light
18.
Jason Flannick, William L. Lowe
19. From Association to Function:
Amélie Bonnefond, Valeriya Lyssenko
Part IV. Clinical Translation
20. Type 2 Diabetes Prediction
Shuai Wang, Frank B. Hu, Josée Dupuis
21. The Value of Genetic Variation in the Prediction of Obesity
Ruth J. F. Loos, A. Cecile J. W. Janssens
22. Pharmacogenetics of Metformin
Sook Wah Yee, Kaixin Zhou, Kathleen M. Giacomini
23. Pharmacogenetics of Sulfonylureas
Peter Kovacs, Ewan Pearson
24. Causal Inference in Medicine via Mendelian Randomization
Timothy M. Frayling, Benjamin F. Voight
25. Diabetes Prevention
Marie-France Hivert, William C. Knowler
26. Nutrigenetics of Type 2 Diabetes
Lu Qi, Paul W. Franks
27. Epilogue: What the Future Holds: Genomic Medicine at the Heart of Diabetes Management
Mark I. McCarthy, David Altshuler, Michael Boehnke
Nyckelord: Biomedicine, Human Genetics, Diabetes, Human Physiology
- Utgivare
- Florez, Jose C.
- Utgivare
- Springer
- Utgivningsår
- 2016
- Språk
- en
- Utgåva
- 1
- Sidantal
- 11 sidor
- Kategori
- Hälsa, skönhet, mode
- Format
- E-bok
- eISBN (PDF)
- 9783319015743
- Tryckt ISBN
- 978-3-319-01573-6