Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products

Part I. Introduction

1. Sunscreen Cosmetics: Advantages and Drawbacks
Zacarías León González

Part II. In Vitro Methodology

2. Development of a Chromatographic Method to Estimate the In Vitro Percutaneous Absorption of Hydrosoluble UV Filters
Zacarías León González

Part III. In Vivo Methodology

3. Determination of the Unconjugated Forms of Benzophenone-3 and Benzophenone-4 in Urine by Solid-Phase Extraction Coupled to a Liquid Chromatographic System with UV/Vis Detection by Using Automated Sequential Injection Analysis
Zacarías León González

4. Determination of Benzophenone-3 and Their Metabolites in Urine by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry
Zacarías León González

5. Determination of Benzophenone-3 and its Metabolites in Human Semen by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry
Zacarías León González

6. Elucidation of the In Vitro Biotransformation Products of Ethylhexyl Dimethyl PABA by Chromatographic Techniques Coupled to Mass Spectrometry
Zacarías León González

7. Elucidation of the In Vivo Biotransformation Products of Ethylhexyl Dimethyl PABA by Liquid Chromatographic Techniques with Mass Spectrometry Detectors
Zacarías León González

8. Determination of Ethylhexyl Dimethyl PABA and its Metabolites in Semen by Automated Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry
Zacarías León González

9. Determination of Methyl Benzylidene Camphor and its Main Metabolite in Urine by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry
Zacarías León González

Part IV. Summary and General Conclusions

10. Highlights of the Ph.D. Thesis
Zacarías León González

Nyckelord: Chemistry, Analytical Chemistry, Pharmacology/Toxicology, Biological Techniques