Mitochondrial DNA, Mitochondria, Disease and Stem Cells

1. Clinical Approach to the Diagnosis of Mitochondrial Disease
Dominic Thyagarajan

2. Mitochondrial DNA Mutations and Their Effects on Complex I Biogenesis: Implications for Metabolic Disease
Matthew McKenzie

3. Embryonic Stem Cells: A Signalling Perspective
Marios P. Stavridis

4. From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) a Mitochondrial Odyssey
João Ramalho-Santos, Ana Sofia Rodrigues

5. From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases
João Facucho-Oliveira, Tejal Kulkarni, Gisela Machado-Oliveira, Justin C. St. John

6. The Role of Mitochondrial DNA in Tumorigenesis
Ka Yu Yeung, Adam Dickinson, Justin C. St. John

7. Assisted Reproductive Technologies: The Potential to Prevent the Transmission of Mutant mtDNA from One Generation to the Next
Richard D. W. Kelly, Arsalan Mahmud, Justin C. St. John

Nyckelord: Life Sciences, Stem Cells, Cell Biology, Cell Physiology