New Strategies in Stroke Intervention

1. Basis of Ionic Dysregulation in Cerebral Ischemia
Thiruma V Arumugam, Eitan Okun, Mark P Mattson

2. Why have Ionotropic and Metabotropic Glutamate Antagonists Failed in Stroke Therapy?
Gianfranco Di Renzo, Giuseppe Pignataro, Lucio Annunziato

3. Mitochondrial Channels as Potential Targets for Pharmacological Strategies in Brain Ischemia
Rosemary H Milton, Michael R Duchen

4. Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke
Alexei Verkhratsky

5.
The Na

+

/Ca

2+

Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia

Lucio Annunziato, Pasquale Molinaro, Agnese Secondo, Anna Pannaccione, Antonella Scorziello, Giuseppe Pignataro, Ornella Cuomo, Rossana Sirabella, Francesca Boscia, Alessandra Spinali, Gianfranco Di Renzo

6.
The “Loop” Diuretic Drug Bumetanide-Sensitive Na

+

-K

+

-Cl

-

Cotransporter in Cerebral Ischemia

Dandan Sun

7.
The Na

+

/H

+

Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia

Jin Xue, Gabriel G. Haddad

8.
The Na

+

/K

+

-ATPase as a Drug Target for Ischemic Stroke

Melissa A Gottron, Donald C Lo

9. Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment
Giuseppe Pignataro

10. Role of TRPM7 in Ischemic CNS Injury
Michael F. Jackson*, Hong-Shuo Sun*, Michael Tymianski, John F. MacDonald

11.
Subtypes of Voltage-Gated Ca

2+

Channels and Ischemic Brain Injury

Soon-Tae Lee, Daejong Jeon, Kon Chu

12.
The Diverse Roles of K

+

Channels in Brain Ischemia

Hiroaki Misonou, James S. Trimmer

13. Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke
Alessandra Spinali, Giuseppe Pignataro, Gianfranco Di Renzo, Lucio Annunziato

Nyckelord: Biomedicine, Neurosciences, Neurology, Cardiology, Molecular Medicine, Pharmacology/Toxicology, Anesthesiology