Checkpoint Controls and Targets in Cancer Therapy

1. Evasion of G1 Checkpoints in Cancer
Krijn K. Dijkstra, Cristophe Blanchetot, Johannes Boonstra

2. Distinct Pathways Involved in S-Phase Checkpoint Control
Paula J. Hurley, Fred Bunz

3. Mechanisms of G2 Phase Arrest in DNA Damage-Induced Checkpoint Response
Jian Kuang, Ruoning Wang

4. Centrosomes in Checkpoint Responses
Alwin Krämer

5. Interplay of 14-3-3 Family of Proteins with DNA Damage-Regulated Molecules in Checkpoint Control
Mong-Hong Lee, Sai-Ching Jim Yeung, Heng-Yin Yang

6. Chromatin Modifications and Orchestration of Checkpoint Response in Cancer
Makoto Nakanishi

7. DNA Damage Response and the Balance Between Cell Survival and Cell Death
Bernd Kaina, Wynand P. Roos, Markus Christmann

8. Dysfunction of the RB Retinoblastoma Gene in Cancer
Francesca Pentimalli, Letizia Cito, Antonio Giordano

9. G1 Phase Cyclins in Cancer Development and Progression
John Patrick Alao

10. The BRCA1/2 Pathway Prevents Some Leukemias and Lymphomas in Addition to Breast/Ovarian Cancers: Malignancies that Overcome Checkpoint Controls
Bernard Friedenson

11. Regulation of p53 Activity and Associated Checkpoint Controls
Sean M. Post, Alfonso Quintás-Cardama, Guillermina Lozano

12. The Importance of p53 Signaling in the Response of Cells to Checkpoint Inhibitors
Alan Eastman

13. Targeting p21-Dependent Pathways for Cell Death in Cancer Therapy
Zahid H. Siddik

14. p27Kip1 as a Biomarker and Target for Treatment of Cancer
Xiao-Feng Le, Robert C. Bast

15. Targeting Cyclin-Dependent Kinases with Small Molecule Inhibitors
Paolo Pevarello, James R. Bischoff, Ciro Mercurio

16. Chk1 and Chk2 as Checkpoint Targets
Haiying Zhang, Zhan Xiao, Tom Sowin

17. Targeting Cdc25 Phosphatases in Cancer Therapy
Johannes Rudolph

Nyckelord: Biomedicine, Cancer Research, Oncology, Pharmacology/Toxicology