Asymptomatic Atherosclerosis

1. Preventive Cardiology: The SHAPE of the Future
Morteza Naghavi

2. From Vulnerable Plaque to Vulnerable Patient
Morteza Naghavi, Erling Falk

3. Pathology of Vulnerability Caused by High-Risk (Vulnerable) Arteries and Plaques
Troels Thim, Mette Kallestrup Hagensen, Jacob Fog Bentzon, Erling Falk

4. Pathophysiology of Vulnerability Caused by Thrombogenic (Vulnerable) Blood
Giovanni Cimmino, Borja Ibanez, Juan Jose Badimon

5. Vulnerability Caused by Arrhythmogenic Vulnerable Myocardium
Ariel Roguin

6. Approach to Atherosclerosis as a Disease: Primary Prevention Based on the Detection and Treatment of Asymptomatic Atherosclerosis
Morteza Naghavi, Erling Falk, Khurram Nasir, Harvey S. Hecht, Matthew J. Budoff, Zahi A. Fayad, Daniel S. Berman, Prediman K. Shah

7. History of the Evolution of Cardiovascular Risk Factors and the Predictive Value of Traditional Risk-Factor-Based Risk Assessment
Amit Khera

8. Comprehensive Lipid Profiling Beyond LDL
Benoit J. Arsenault, S. Matthijs Boekholdt, John J. P. Kastelein, Jean-Pierre Després

9. New Blood Biomarkers of Inflammation and Atherosclerosis
Natalie Khuseyinova, Wolfgang Koenig

10. Genomics and Proteomics: The Role of Contemporary Biomolecular Analysis in Advancing the Knowledge of Atherosclerotic Coronary Artery Disease
Gary P. Foster, Naser Ahmadi

11. Circulating Endothelial Progenitor Cells: Mechanisms and Measurements
Jonathan R. Murrow, Arshed A. Quyyumi

12. Family History: An Index of Genetic and Environmental Predisposition to Coronary Artery Disease
Shivda Pandey, Khurram Nasir

13. Endothelial Activation Markers in Sub-clinical Atherosclerosis: Insights from Mechanism-Based Paradigms
Victoria L. M. Herrera, Joseph A. Vita

14. Exercise Stress Testing in Asymptomatic Individuals and Its Relation to Subclinical Atherosclerotic Cardiovascular Disease
Kevin S. Heffernan

15. The Ankle Brachial Index
Matthew A. Allison, Mary M. McDermott

16. Arterial Elasticity/Stiffness
Daniel A. Duprez, Jay N. Cohn

17. Assessment of Endothelial Function in Clinical Practice
Jeffrey T. Kuvin

18. Digital (Fingertip) Thermal Monitoring of Vascular Function: A Novel, Noninvasive, Nonimaging Test to Improve Traditional Cardiovascular Risk Assessment and Monitoring of Response to Treatments
Matthew Budoff, Naser Ahmadi, Stanley Kleis, Wasy Akhtar, Gary McQuilkin, Khawar Gul, Timothy O’Brien, Craig Jamieson, Haider Hassan, David Panthagani, Albert Yen, Ralph Metcalfe, Morteza Naghavi

19. Assessment of Macro- and Microvascular Function and Reactivity
Craig J. Hartley, Hirofumi Tanaka

20. Coronary Artery Calcium Imaging
Harvey S. Hecht

21. Noninvasive Ultrasound Imaging of Carotid Intima Thickness
Tasneem Z. Naqvi

22. Carotid Intima-Media Thickness: Clinical Implementation in Individual Cardiovascular Risk Assessment
Ward A. Riley

23. Computed Tomographic Angiography
Harvey S. Hecht

24. Role of Noninvasive Imaging using CT for Detection and Quantitation of Coronary Atherosclerosis
John A. Rumberger

25. Noninvasive Coronary Plaque Characterization: CT Versus MRI
John A. Rumberger

26. Magnetic Resonance Imaging
Zahi A. Fayad

27. The Role of MRI in Examining Subclinical Carotid Plaque
Chun Yuan, Hideki Ota, Xihai Zhao, Tom Hatsukami

28. Comprehensive Non-contrast CT Imaging of the Vulnerable Patient
Damini Dey, Ioannis A. Kakadiaris, Matthew J. Budoff, Morteza Naghavi, Daniel S. Berman

29. Ultrasound Assessment of Brachial Artery Reactivity
A. Rauoof Malik, Iftikhar J. Kullo

30. Cardiac Imaging for Ischemia in Asymptomatic Patients: Use of Coronary Artery Calcium Scanning to Improve Patient Selection: Lessons from the EISNER Study
Alan Rozanski, Heidi Gransar, Nathan D. Wong, Leslee J. Shaw, Michael J. Zellweger, Daniel S. Berman

31. Targeted MRI of Molecular Components in Atherosclerotic Plaque
Zahi A. Fayad

32. Noninvasive Imaging of the Vulnerable Myocardium: Cardiac MRI and CT Based
Ricardo C. Cury, Anand Soni, Ron Blankstein

33. Angiography for Detection of Complex and Vulnerable Atherosclerotic Plaque
James A. Goldstein

34. Intravascular Characterization of Vulnerable Coronary Plaque
James A. Goldstein, James E. Muller

35. Detecting Vulnerable Plaque Using Invasive Methods
Robert S. Schwartz, Arturo G. Touchard

36. Assessment of Plaque Burden and Plaque Composition Using Intravascular Ultrasound
Paul Schoenhagen, Anuja Nair, Stephen Nicholls, Geoffrey Vince

37. Vulnerable Anatomy; The Role of Coronary Anatomy and Endothelial Shear Stress in the Progression and Vulnerability of Coronary Artery Lesions: Is Anatomy Destiny?

Charles L. Feldman, Yiannis S. Chatzizisis, Ahmet U. Coskun, Konstantinos C. Koskinas, Morteza Naghavi, Peter H. Stone

38. Vasa Vasorum Imaging
Ioannis A. Kakadiaris, Sean O’Malley, Manolis Vavuranakis, Ralph Metcalfe, Craig J. Hartley, Erling Falk, Morteza Naghavi

39. From Vulnerable Plaque to Vulnerable Patient – Part III
Morteza Naghavi, Erling Falk, Harvey S. Hecht, Michael J. Jamieson, Sanjay Kaul, Daniel S. Berman, Zahi Fayad, Matthew J. Budoff, John Rumberger, Tasneem Z. Naqvi, Leslee J. Shaw, Jay N. Cohn, Ole Faergeman, Raymond D. Bahr, Wolfgang Koenig, Jasenka Demirovic, Dan Arking, Victoria L. M. Herrera, Juan Jose Badimon, James A. Goldstein, Arturo G. Touchard, Yoram Rudy, K. E. Juhani Airaksinen, Robert S. Schwartz, Ward A. Riley, Robert A. Mendes, Pamela S. Douglas, Prediman K. Shah

40. Cost Effectiveness of Screening Atherosclerosis
Leslee J. Shaw, Ron Blankenstein

41. Monitoring of Subclinical Atherosclerotic Disease
Daming Zhu, Allen J. Taylor, Todd C. Villines

42. Implications of SHAPE Guideline for Improving Patient Compliance
Matthew J. Budoff

43. The SHAPE Guideline: Why Primary Care Physicians Should Embrace It
Robert A. Mendes

44. Should We Treat According to the SHAPE Guidelines?
Paolo Raggi, Stamatios Lerakis

45. Duty-Bound: Rational Foundations of Clinical Strategies for Prevention of Cardiovascular Events
George A. Diamond, Sanjay Kaul

46. A Time to Live: Dynamic Changes in Risk as the Basis for Therapeutic Triage
Sanjay Kaul, George A. Diamond

47. LDL Targeted Therapies
Raul D. Santos, Khurram Nasir, Roger S. Blumenthal

48. Antioxidants as Targeted Therapy: A Special Protective Role for Pomegranate and Paraoxonases (PONs)
Mira Rosenblat, Michael Aviram

49. The Multiconstituent Cardiovascular Pill (MCCP): Challenges and Promises of Population Based Prophylactic Drug Therapy for Heart Attack Prevention and Eradication
Michael J. Jamieson, Harvey S. Hecht, Morteza Naghavi

50. Vaccine for Atherosclerosis: An Emerging New Paradigm
Prediman K. Shah, Kuang-Yuh Chyu, Jan Nilsson, Gunilla N. Fredrikson

51. Drug-Eluting Stents: A Potential Preemptive Treatment Choice for Vulnerable Coronary Plaques
Edwin Lee, George Dangas, Roxana Mehran

52. Intrapericardial Approach for Pancoronary Stabilization of the Vulnerable Arteries and Myocardium
Venkatesan Vidi, Sergio Waxman

53. Dietary Management for Coronary Atherosclerosis Prevention and Treatment
Michel Lorgeril, Patricia Salen

54. Management of Preconditioning Physical Activity in a Vulnerable Patient: Getting in SHAPE
Sae Young Jae

55. Last Chance for Prevention (Acute Prevention): Identification of Prodromal Symptoms and Early Heart Attack Care
Raymond D. Bahr, Yasmin S. Hamirani, Morteza Naghavi

Nyckelord: Medicine & Public Health, Cardiology, Internal Medicine, General Practice / Family Medicine, Primary Care Medicine