The Cannabinoid Receptors

Part I. Cannabinoid Receptor Ligands and Structure-Activity Relationships

1. Structure–Activity Relationships of Classical Cannabinoids
Raj K. Razdan

2. Endocannabinoids and Their Synthetic Analogs
V. Kiran Vemuri, Alexandros Makriyannis

3. Cannabimimetic Indoles, Pyrroles, and Indenes: Structure–Activity Relationships and Receptor Interactions
John W. Huffman

4. Structure–Activity Relationships and Conformational Freedom of CB1 Receptor Antagonists and Inverse Agonists
Yanan Zhang, Herbert H. Seltzman, Marcus Brackeen, Brian F. Thomas

Part II. Cannabinoid Receptor Biology

5. Cannabinoid Receptor Genetics and Evolution
Maurice R. Elphick, Michaela Egertová

Part III. Cannabinoid Receptor Molecular Pharmacology

6. Cannabinoid Receptor Signal Transduction Pathways
Emma Scotter, Scott Graham, Michelle Glass

7. Cannabinoid Agonist and Inverse Agonist Regulation of G Protein Coupling
Allyn C. Howlett, Lea W. Padgett, Joong-Youn Shim

8. Molecular Biology of Cannabinoid Receptors: Mutational Analyses of the CB Receptors
Mary E. Abood

9. Models of Cannabinoid Inverse Agonism, Neutral Antagonism, and Agonism: Tools for Rational Drug Design
Dow P. Hurst, Patricia H. Reggio

Part IV. The Endocannabinoid System

10. Endocannabinoids as Modulators of Synaptic Signaling
Sachin Patel, Cecilia J. Hillard

11. New Insights into the Endocannabinoid System by Using Cannabinoid Receptor Knockout Mice
Meliha Karsak, Itai Bab, Andreas Zimmer

Part V. Cannabinoid Receptor Pharmacology

12. Preclinical Pharmacological and Brain Bioassay Systems for CB1 Cannabinoid Receptors
Jenny L. Wiley, Billy R. Martin

13. Therapeutic Applications for Agents that Act at CB1 and CB2 Receptors
Roger G. Pertwee, Adèle Thomas

Nyckelord: TECHNOLOGY & ENGINEERING / Biomedical TEC059000