Sourcebook of Models for Biomedical Research

I.Introduction

1. Animal Models for Human Diseases
Jann Hau

2. Selection of Biomedical Animal Models
Michael S. Rand

3. Improved Models for Animal Research
Rolf Sprengel, Leonid Eshkind, Jan Hengstler, Ernesto Bockamp

II.General Considerations

4. The Ethical Basis for Animal Use in Research
James Parker

5. Bibliographic Searching Tools on Disease Models to Locate Alternatives for Animals in Research
Mary W. Wood, Lynette A. Hart

6. NIH Policies on Sharing of Model Organisms and Related Research Resources
J. P. Kim, Charlene Cho, Norka Ruiz Bravo

7. Databases for Biomedical Animal Resources
Richard L. Crawford, Tim Allen

8. Psychological Enrichment for Animals in Captivity
Coleman Kristine

III.Well-Established Models

9. Integrated Network Modeling of Molecular and Genetic Interactions
Gregory W. Carter, Vesteinn Thorsson, Timothy Galitski

10. The Sponge as a Model of Cellular Recognition
Xavier Fernàndez-Busquets

11. Sea Urchin Embryo
Tetsuya Kominami, Hiromi Takata

12. Caenorhabditis elegans Models of Human Neurodegenerative Diseases
Richard Nass, Lihsia Chen

13. Zebrafish as a Model for Development
Brian A. Link, Sean G. Megason

14. Zebrafish as a Model for Studying Adult Effects of Challenges to the Embryonic Nervous System
Nicole Marie Roy, Elwood A. Linney

15. Modeling Cognitive and Neurodegenerative Disorders in Drosophila melanogaster
Junjiro Horiuchi, Minoru Saitoe

16. Biomedical Research with Honey Bees
Michelle M. Elekonich

17. Establishing and Maintaining a Xenopus laevis Colony for Research Laboratories
Punita Koustubhan, Debra Sorocco, Michael S. Levin

18. The Chicken as a Model Organism
Janice M. Bahr

19. Rat Knockout and Mutant Models
Bart M. G. Smits, Jill D. Haag, Michael N. Gould, Edwin Cuppen

20. Rodent Genetics, Models, and Genotyping Methods
Sheryl J. Wildt, Andrew I. Brooks, Robert J. Russell

21. The House Mouse in Biomedical Research
John G. Vandenbergh

22. Mouse Model for Alzheimer’s Disease
M. Azhar Chishti, Shaheen M. Nakeeb

23. Guinea Pigs as Models for Human Cholesterol and Lipoprotein Metabolism
Maria Luz Fernandez, Richard J. Wood

24. Reliability of Rodent Models
Dileep Kumar Rohra, Yureeda Qazi

25. The Domestic Cat, Felis catus, as a Model of Hereditary and Infectious Disease
Marilyn Menotti-Raymond, Stephen J. O’Brien

26. Swine in Biomedical Research
M. Michael Swindle, Alison C. Smith

27. The Minipig as an Animal Model in Biomedical Stem Cell Research
Petr Vodicka, Jana Hlucilova, Jiri Klima, Radek Prochazka, Jitka Ourednik, Vaclav Ourednik, Jan Motlik

28. The Nonhuman Primate as a Model for Biomedical Research
David M. Anderson

29. Primates as Models of Behavior in Biomedical Research
Steven J. Schapiro

30. Primate Models for Understanding Brain Mechanisms of Cognitive Behavior
Ronald E. Kettner, M. Lysetskiy, M. Suh

IV.Models for Specific Purposes

31. Animal Models for Eye Diseases and Therapeutics
Takeshi Iwata, Stanislav Tomarev

32. Animal Models of Noise-Induced Hearing Loss
Richard Salvi, Flint A. Boettcher

33. Human and Animal Models for the Study of Muscle Pain
Norman F. Capra, Jin Y. Ro

34. Animal Models of Parkinson’s Disease
Emma L. Lane, Thomas Carlsson, Deniz Kirik, Stephen B. Dunnett

35. Transgenic Animal Models of Neurodegenerative Diseases
Anthony W. S. Chan, Yuksel Agca

36. Animal Models of Nociception and Pain
James D. Rose, C. Jeffrey Woodbury

37. Nonmammalian Models for the Study of Pain
Craig W. Stevens

V.Models of Behavior

38. Animal Models of Vascular Development and Endothelial Cell Biology
Victoria L. Bautch

39. Models of Behavior
Lina Badimon, Laura Casaní, Gemma Vilahur

40. Animal Models for Atherosclerosis, Restenosis, and Endovascular Aneurysm Repair
András Kónya, Kenneth C. Wright, Matthew Gounis, Krishna Kandarpa

41. Transgenic mouse models of HIV-1/AIDS and cardiac performance
James J. Kohler, William Lewis

42. Primate Models for the Assisted Reproductive Technologies and Embryonic Stem Cell Biology
Don P. Wolf, Shoukhrat Mitalipov, James A. Byrne

43. Rat Models of Polycystic Ovary Syndrome
Krishna B. Singh

44. Murine Models for Reproduction
Damayanti Chakraborty, T. Rajendra Kumar

45. Pig Model to Study Dynamics of Steroids During Ovarian Follicular Growth and Maturation
Damodar K. Mahajan

46. Molecular Genetic Approach to Identify Inhibitors of Signal Transduction Pathways
Shunji Ishiwata, Takayoshi Kuno, Hirofumi Takada, Atsushi Koike, Reiko Sugiura

47. Yeast as a Model System to Study DNA Damage and DNA Repair
Antonio Conconi

48. Human Models of Space Physiology
Victor A. Convertino, Caroline A. Rickards

49. Developmental Space Biology of Mammals
April E. Ronca

50. A Practical Approach to Animal Models of Sepsis
Bryan Belikoff, Jon A. Buras

51. Animal Models in Functional Magnetic Resonance Imaging
Afonso C. Silva, Bojana Stefanovic

52. Animal Models in Aging Research
Rochelle Buffenstein, Yael H. Edrey, Pamela L. Larsen

53. Gene Targeting in Human Somatic Cells
Eric A. Hendrickson

54. Animal Models for Investigating the Causes and Mechanisms of Mammalian Germ Cell Aneuploidy
John B. Mailhes, Mary Ann Handel

55. Genetic Models of Alzheimer’s Disease
Yann S. Mineur

56. Rat Models of Experimental Autoimmune Encephalomyelitis
Erik Wallström, Tomas Olsson

57. Animal Models in Virology
Joseph L. Bryant

58. Nonhuman Primate Models for AIDS
Nancy L. Haigwood, Raymond R. O’Neill, Vanessa M. Hirsch

VI.Models of Other Human Diseases

59. Use of Congenic Mouse Strains for Candidate Disease Gene Identification in Complex Traits
Ute Christine Rogner, Philip Avner

60. Animal Models of Sudden Infant Death Syndrome
Jane Blood-Siegfried

61. Animal Models of Posttraumatic Stress Disorder
Hagit Cohen, Michael A. Matar, Joseph Zohar

62. Animal Models for Studying Fetal Alcohol Syndrome, Alcohol-Related Birth Defects, and Alcohol-Related Neurodevelopmental Disorder
Timothy A. Cudd

63. Modeling Drug and Alcohol Abuse
Robert T. Gerlai

64. Mouse Models for Experimental Cancer Therapy
Sara Rockwell, Karen R. Rockwell

65. Rat Models of Skin Wound Healing
Wanda A. Dorsett-Martin, Annette B. Wysocki

66. Animal Models of Prostate Cancer
Adebusola A. Alagbala, Barbara A. Foster

67. Animal Models of Diabetes
Willy J. Malaisse, Abdullah Sener

68. Animal Models of Kidney Diseases
Chunsun Dai, Lawrence P. Kiss, Youhua Liu

69. Animal Models of Multiple Sclerosis
Colin R. Young, C. Jane Welsh

70. Canine and Feline Models for Cancer
Gionata Vico, Paola Maiolino

71. Obese Mouse Models
Deborah J. Good

72. Study of Polycystic Kidney Disease in the Nematode Caenorhabditis elegans
Matthew J. Buechner

73. Animal Models of Myelofibrosis
Alessandro M. Vannucchi, Jean-Luc Villeval, Orianne Wagner-Ballon, Paola Guglielmelli, Anna Rita Migliaccio

74. Animal Models for Bone Tissue Engineering Purposes
Véronique Viateau, Delphine Logeart-Avramoglou, Geneviève Guillemin, Hervé Petite

VII.Other Tools

75. Markov Processes for Biomedical Data Analysis
Ricardo Ocaña-Riola

76. Software Tools for Modeling Biomedical Systems
Karl Thomaseth

77. Developing Websites for Biomedical Research and Training
Krishna B. Singh

78. Building Virtual Research Communities Using Web Technology
Krishna B. Singh

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Nyckelord: MEDICAL / Public Health MED078000