Antiangiogenic Agents in Cancer Therapy

I. Basic Biology of Angiogenesis

1. Vascular Endothelial Growth Factor Family and Its Receptors
Daniel J. Hicklin

2. The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors
Mark W. Dewhirst, Yiting Cao, Gordana Vlahovic

3. The Role of Integrins in Tumor Angiogenesis
Aparna R. Aiyer, Judith A. Varner

4. Tumor Endothelial Cell Abnormalities
Andrew C. Dudley, Michael Klagsbrun

5. The Extracellular Matrix and VEGF Processing
Sunyoung Lee, M. Luisa Iruela-Arispe

6. Endothelial Precursor Cells
Rebecca G. Bagley

7. Role of Pericytes in Angiogenesis
Chunhua Lu, Anil K. Sood

8. Newer Vascular Targets
Beverly A. Teicher

9. Chemokines in Angiogenesis
Michael P. Keane, John A. Belperio, Robert M. Strieter

10. Angiopoietin/Tie2 Signaling Regulates Tumor Angiogenesis
Hanako Kobayashi, Laura M. DeBusk, P. Charles Lin

11. Imaging Angiogenesis
Sanjeeva P. Kalva, Saravanan Namasivayam, Dushyant Vasuedeo Sahani

12. Tumor Blood Vessels
Yineng Fu, Janice A. Nagy, Ann M. Dvorak, Harold F. Dvorak

13. Lymphatic System in the Pathology of Cancer
Bronislaw Pytowski

II. Translational Research in Tumor Angiogenesis

14. VEGF in the Adult
Arindel S.R. Maharaj, Patricia A. D’Amore

15. Normalization of Tumor Vasculature and Microenvironment
Rakesh K. Jain, Tracy T. Batchelor, Dan G. Duda, Christopher G. Willett

16. Metronomic Low-Dose Antiangiogenic Chemotherapy in Mice and Man
Robert S. Kerbel, U. Emmenegger, S. Man, R. Munoz, C. Folkins, Y. Shaked

17. Small-Molecule Vascular Disrupting Agents in Cancer Therapy
Dietmar W. Siemann, Michael R. Horsman

18. Normalization of Tumor Vasculature and Improvement of Radiation Response by Antiangiogenic Agents
Erin Mendoza, Randy Burd, Phyllis Wachsberger, Adam P. Dicker

19. Challenges in Translating Antiangiogenic Therapy from the Bench to Bedside
Lee M. Ellis, Nikolaos A. Dallas, George van Buren, Sherry Lim, Ling Xia, Fan Fan, Michael J. Gray

20. Regulation of Angiogenesis in Cancer and Its Therapeutic Implications
Liangfeng Han, Annaka M. Lorincz, Saraswati Sukumar

III. Antiangiogenic Therapy in the Clinical Trial Results and Future Directions

21. Angiogenesis and Angiogenesis Inhibition in Sarcomas
Steven DuBois, George Demetri

22. Antiangiogenesis Agents in Colorectal Cancer
Axel Grothey

23. Antiangiogenic Therapy for Primary CNS Tumors
Katherine E. Warren, Howard A. Fine

24. Angiogenesis Inhibitors for the Treatment of Lung Cancer
Monique B. Nilsson, Emer O. Hanrahan, John V. Heymach

25. Antiangiogenic Therapy of Renal Cell Carcinoma
Michael S. Gordon, Scot W. Ebbinghaus

26. Antiangiogenesis Therapies in Gynecologic Malignancies
Robert A. Burger

27. Antiangiogenic Agents in Myeloid Malignancies
Magda Melchert, Alan F. List

28. Angiogenesis in Malignant and Non-Malignant Pediatric Tumors
Domenico Ribatti, Mirco Ponzoni

29. Prognostic and Predictive Significance of Surrogate Biomarkers of Angiogenesis
Raffaele Longo, Francesco Torino, Giampietro Gasparini

30. Endpoints for the Determination of Efficacy of Antiangiogenic Agents in Clinical Trials
Joseph Paul Eder, Dan S. Zuckerman

31. The Role of Imaging in the Clinical Development of Antiangiogenic Agents
Andrew R. Clamp, Gordon C. Jayson

Nyckelord: Biomedicine, Cancer Research, Oncology, Surgical Oncology, Pharmacology/Toxicology