Alcohol Use Disorders and the Lung

Part I. The Epidemiology of Alcohol Use and Lung Health

1. A Brief History of Alcohol Use and Abuse in Human History
David M. Guidot, Ashish J. Mehta

2. Overview of the Evolving Recognition of the Health Effects of Excessive Alcohol Use Over the Past Two Centuries Including the Classic Citations
David M. Guidot, Ashish J. Mehta

3. Current Definitions of Alcohol Use Disorders and the Use of Validated Questionnaires in Clinical Practice and Research
Karen Drexler

4. The Epidemiology of Alcohol Abuse and Pneumonia
Kyle I. Happel

5. The Epidemiology of Alcohol and Acute Respiratory Distress Syndrome
Brendan J. Clark, Ellen L. Burnham

Part II. The Pathophysiology of the “Alcoholic Lung”

6. Alcohol, the Upper Airway, and Mucociliary Dysfunction in the Conducting Airways
Todd A. Wyatt, Joseph H. Sisson

7. Alcohol and the Alveolar Macrophage
Samantha M. Yeligar, Yan Liang, Lou Ann S. Brown

8. Alcohol and the Alveolar Epithelium
Samuel A. Molina, Michael Koval

9. Alcohol-Mediated Oxidative Stress in the Airway: The Unique Role of Thiol Depletion
Samantha M. Yeligar, Yan Liang, Lou Ann S. Brown

10. Alcohol and the Adaptive Immune Response in the Airway: Dendritic Cell and Lymphocyte Impairments
Kevin L. Legge, Thomas J. Waldschmidt

11. Alcohol Impairment of Granulocyte Function During Lung Infection
Gregory J. Bagby, Kyle I. Happel, J. Nicholas Melvan

12. Disruption in the Dynamic Balance Between Transforming Growth Factor-β and Granulocyte/Macrophage Colony-Stimulating Factor Signaling Within the Alveolar Space of the Alcoholic Lung: Impact on Epithelial and Macrophage Function
David M. Guidot, Ashish J. Mehta

13. Alcohol-Mediated Zinc Deficiency Within the Alveolar Space: A Potential Fundamental Mechanism Underlying Oxidative Stress and Cellular Dysfunction in the Alcoholic Lung
Ashish J. Mehta, David M. Guidot

Part III. Special Circumstances

14. The Impact of Alcohol Abuse on Multiple Organ Dysfunction in the Surgical Patient
Katharina Chalk, Claudia Spies

15. Alcohol and HIV: Experimental and Clinical Evidence of Combined Impact on the Lung
Sushma K. Cribbs, David Rimland

16. Maternal Alcohol Use and the Neonate
Theresa W. Gauthier, Danielle Giliberti, Sowmya S. Mohan, Juna Konomi, Lou Ann S. Brown

Nyckelord: Medicine & Public Health, Pneumology/Respiratory System, Intensive / Critical Care Medicine, Psychiatry, Internal Medicine